+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships

Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships

Fungal Biology and Biotechnology 5: 12

Cytochrome P450s form an important group of enzymes involved in xenobiotics degradation and metabolism, both primary and secondary. These enzymes are also useful in industry as biotechnological tools for bioconversion and a few are reported to be involved in pathogenicity. Trichoderma spp. are widely used in industry and agriculture and are known for their biosynthetic potential of a large number of secondary metabolites. For realising the full biosynthetic potential of an organism, it is important to do a genome-wide annotation and cataloguing of these enzymes. Here, we have studied the genomes of seven species (T. asperellum, T. atroviride, T. citrinoviride, T. longibrachiatum, T. reesei , T. harzianum and T. virens) and identified a total of 477 cytochrome P450s. We present here the classification, evolution and structure as well as predicted function of these proteins. This study would pave the way for functional characterization of these groups of enzymes and will also help in realization of their full economic potential. Our CYPome annotation and evolutionary studies of the seven Trichoderma species now provides opportunities for exploration of research-driven strategies to select Trichoderma species for various applications especially in relation to secondary metabolism and degradation of environmental pollutants.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 065173424

Download citation: RISBibTeXText

PMID: 29881631

DOI: 10.1186/s40694-018-0056-3

Related references

Genome-Wide Annotation and Comparative Analysis of Cytochrome P450 Monooxygenases in Basidiomycete Biotrophic Plant Pathogens. Plos One 10(11): E0142100, 2016

A genome-wide analysis of coatomer protein (COP) subunits of apicomplexan parasites and their evolutionary relationships. Bmc Genomics 20(1): 98, 2019

Genome-wide annotation of remorins, a plant-specific protein family: evolutionary and functional perspectives. Plant Physiology 145(3): 593-600, 2007

Genome-Wide Annotation of Remorins, a Plant-Specific Protein Family: Evolutionary and Functional Perspectives. Plant Physiology 145(3): 593-600, 2007

An evaluation of noncoding genome annotation tools through enrichment analysis of 15 genome-wide association studies. Briefings in Bioinformatics 2017, 2017

Genome-wide comparative analysis of H3K4me3 profiles between diploid and allotetraploid cotton to refine genome annotation. Scientific Reports 7: 9098, 2017

Genome Sequence and Annotation of Trichoderma parareesei, the Ancestor of the Cellulase Producer Trichoderma reesei. Genome Announcements 3(4), 2015

A genome-wide analysis of array-based comparative genomic hybridization (CGH) data to detect intra-species variations and evolutionary relationships. Plos One 4(11): E7978, 2010

Genome analysis of cytochrome P450s and their expression profiles in insecticide resistant mosquitoes, Culex quinquefasciatus. Plos One 6(12): E29418, 2012

Genome Analysis of Cytochrome P450s and Their Expression Profiles in Insecticide Resistant Mosquitoes, Culex quinquefasciatus. PLoS ONE 6(12): e29418, 1-11, 2011

Evolutionary relationships and the genome-wide screening for gel-forming mucins. FASEB Journal 16(5): A882, March 22, 2002

Expression and characterization of two new alkane-inducible cytochrome P450s from Trichoderma harzianum. Biotechnology Letters 33(6): 1201-1206, 2011

Genome-wide analysis of myxobacterial two-component systems: genome relatedness and evolutionary changes. Bmc Genomics 16: 780, 2016

Curated genome annotation of Oryza sativa ssp japonica and comparative genome analysis with Arabidopsis thaliana - The Rice Annotation Project. Genome Research 17(2): 175-183, 2007

Annotation-based genome-wide SNP discovery in the large and complex Aegilops tauschii genome using next-generation sequencing without a reference genome sequence. Bmc Genomics 12: 59, 2011