+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Hepatocyte-specific contrast media: not so simple

Hepatocyte-specific contrast media: not so simple

Pediatric Radiology 48(9): 1245-1255

Hepatocyte-specific contrast media are gadolinium chelates that are taken up by hepatocytes and partially cleared via the biliary tree. The absence of lesional uptake of the contrast media in the hepatobiliary phase is a marker of either the absence of hepatocytes or of poorly functioning, neoplastic hepatocytes. Uptake of the contrast media in the hepatobiliary phase, whether equal to or greater than background liver, reflects the presence of hepatocytes but does not equate to absence of neoplasia. Accurate diagnosis of liver lesions utilizing hepatocyte-specific contrast media requires an understanding of the mechanisms of uptake and clearance of the contrast media to avoid misdiagnosis. In this review we discuss the mechanisms of hepatocellular transport of hepatocyte-specific contrast media and utilize an understanding of those mechanisms to discuss the imaging appearance of a subset of hepatocellular lesions that can be seen in the pediatric and young adult liver. We pay particular attention to lesions that appear iso- to hyperintense in the hepatobiliary phase but have the potential for adverse clinical outcomes. We also discuss strategies for identifying these lesions.

(PDF emailed within 0-6 h: $19.90)

Accession: 065190021

Download citation: RISBibTeXText

PMID: 30078050

DOI: 10.1007/s00247-018-4108-x

Related references

Hepatocyte-specific contrast media for CT. An experimental investigation. Acta Radiologica. Supplementum 411: 1-27, 1997

Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis. Journal of Magnetic Resonance Imaging 3(5): 786-793, 1993

Enhancement of liver parenchyma after injection of hepatocyte-specific MRI contrast media: a comparison of gadoxetic acid and gadobenate dimeglumine. Journal of Magnetic Resonance Imaging 31(2): 356-364, 2010

Contrast media and metformin: guidelines to diminish the risk of lactic acidosis in non-insulin-dependent diabetics after administration of contrast media. ESUR Contrast Media Safety Committee. European Radiology 9(4): 738-740, 1999

Evaluation of hepatic contrast enhancement with a hepatocyte-specific magnetic resonance imaging contrast agent (gadoxetic acid) in healthy dogs. American Journal of Veterinary Research 76(3): 224-230, 2015

Exponentially Decelerated Contrast Media Injection Rate Combined With a Novel Patient-Specific Contrast Formula Reduces Contrast Volume Administration and Radiation Dose During Computed Tomography Pulmonary Angiography. Journal of Computer Assisted Tomography 40(3): 370-374, 2017

Reaction between x-ray contrast media and dyes and hepatocyte plasma membranes. Farmakologiia i Toksikologiia 44(2): 195-200, 1981

Liver-specific contrast media for magnetic resonance imaging and computed tomography scanning: importance of contrast media for tumor detection in an experimental liver tumor model. Academic Radiology 3 Suppl 2: S420-S422, 1996

Effect of contrast media on the structure and function of hepatocyte plasma membranes. Farmakologiia i Toksikologiia 44(3): 322-326, 1981

Contrast enhanced liver MRI in patients with primary sclerosing cholangitis: inverse appearance of focal confluent fibrosis on delayed phase MR images with hepatocyte specific versus extracellular gadolinium based contrast agents. Academic Radiology 18(12): 1549-1554, 2012

Recommendations of the European Society of Urogenital Radiology on the use of contrast media and the opportunity to use paramagnetic contrast in patients allergic to iodinated contrast media treated with endourology. Actas Urologicas Espanolas 26(10): 820, 2003

Reduced Contrast Volume and Radiation Dose During Computed Tomography of the Pancreas: Timing-Specific Contrast Media Protocol. Academic Radiology 2018, 2018

Reactions to radiographic contrast media: an attempt to detect specific anti-contrast medium antibodies in the sera of reactor patients. British Journal of Radiology 59(702): 531-536, 1986

Selection of contrast medium for CT: what percentage of patients receiving CT needs nonionic contrast media (low-osmolarity contrast media)?. Academic Radiology 5 Suppl 1: S49-50; Discussion S60-2, 1998

Hepatocyte-specific magnetic resonance imaging contrast agents. Hepatology 53(2): 678-682, 2011