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Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells

Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells

Febs Open Bio 8(3): 406-415

Liver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs). Previously, we reported that hypoxia-inducible factor-1 (Hif-1) regulates activation of HSCs through autophagy. In current work, human HSC cell line LX-2 was used as cell model. It was determined that trimethylation of H3 histone on lysine 4 (H3K4me3) occurred in the Hif-1 transcriptional complex. Inhibition of modifications of histone methylation suppressed Hif-1 nuclear transport, autophagosome formation, and activation of LX-2 cells. These data suggest that histone methylation modification plays an important role in the Hif-1 signaling cascade regulating HSC activation.

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Accession: 065197538

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PMID: 29511617

DOI: 10.1002/2211-5463.12379

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