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HPV type determination and clinical characteristics in juvenile onset recurrent respiratory papillomatosis



HPV type determination and clinical characteristics in juvenile onset recurrent respiratory papillomatosis



Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 30(9): 730



Objective:To investigate the relationship between different subtypes of human papillomavirus(HPV) infection and clinical features in juvenile onset recurrent respiratory papillomatosis(JORRP) patients. Method:Two hundred and forty cases with JORRP from 2010 to 2014 were retrospectively analyzed. HPV tpye were determined using tumor specimens taken from surgery, and all patients were divided into different groups based on HPV type. Clinical characteristics of patients from each groups were analyzed. Result:Except for HPV11 single infection or HPV6 single infection, some HPV11 and 6 co-infections were found in children with JORRP. Compared with patients with HPV6 single infection, HPV11 positive patients present an earlier age of onset, more times of operation and higher derkay score during surgery.Conclusion:JORRP in patients infected with HPV11 is more severe than that in patients with HPV6 infection in children.

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Accession: 065204228

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PMID: 29771024


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