+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study



Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study



Biomed Research International 2018: 5362948



We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065214426

Download citation: RISBibTeXText

PMID: 29607322

DOI: 10.1155/2018/5362948


Related references

Giving social support to outside family may be a desirable buffer against depressive symptoms in community-dwelling older adults: Japan gerontological evaluation study. Biopsychosocial Medicine 10: 18, 2016

Effect of the Japanese preventive-care version of the Minimum Data Set--Home Care on the health-related behaviors of community-dwelling, frail older adults and skills of preventive-care managers: a quasi-experimental study conducted in Japan. Geriatrics and Gerontology International 9(3): 310-319, 2009

Mini-Mental State Examination performance in frail, pre-frail, and non-frail community dwelling older adults in Ermelino Matarazzo, São Paulo, Brazil. International Psychogeriatrics 24(11): 1725-1731, 2012

Care-related goals of community-dwelling frail older adults. Journal of the American Geriatrics Society 59(8): 1552-1554, 2011

The association between social participation and cognitive function in community-dwelling older populations: Japan Gerontological Evaluation Study at Taisetsu community Hokkaido. International Journal of Geriatric Psychiatry 32(10): 1131-1140, 2017

Laughter and Subjective Health Among Community-Dwelling Older People in Japan: Cross-Sectional Analysis of the Japan Gerontological Evaluation Study Cohort Data. Journal of Nervous and Mental Disease 203(12): 934-942, 2015

Balance Evaluation of Prefrail and Frail Community-Dwelling Older Adults. Journal of Geriatric Physical Therapy 42(3): 176-182, 2017

Relationship between weight loss, and body composition and hematologic values in Japanese community-dwelling frail older adults. PhysioTherapy 101: E1702-E1703, 2015

What does quality of life mean to older frail and non-frail community-dwelling adults in the Netherlands?. Quality of Life Research 16(2): 263-277, 2007

What Does Quality of Life Mean to Older Frail and Non-Frail Community-Dwelling Adults in the Netherlands?. Quality of Life Research 16(2): 263-277, 2007

Factors associated with falls in community-dwelling older people with focus on participation in sport organizations: the Japan Gerontological Evaluation Study Project. Biomed Research International 2014: 537614, 2014

Impact of a lay-led home-based intervention programme on quality of life in community-dwelling pre-frail and frail older adults: a randomized controlled trial. Bmc Geriatrics 17(1): 154, 2017

Improving Health Related Quality of Life and Independence in Community Dwelling Frail Older Adults through a Client-Centred and Activity-Oriented Program. A Pragmatic Randomized Controlled Trial. Journal of Nutrition Health and Aging 20(1): 35-40, 2016

Improving health related quality of life and independence in community dwelling frail older adults through a client-centred and activity-oriented program. A pragmatic randomized controlled trial. The journal of nutrition, health & aging 20(1): 35-40, 2016

Nitrofurantoin Use in Frail, Community-Dwelling, Older Adults with Renal Impairment. Senior Care Pharmacist 34(5): 303-307, 2019