In Vitro and in Vivo Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis
Shoen, C.; DeStefano, M.; Hafkin, B.; Cynamon, M.
Antimicrobial Agents and ChemoTherapy 62(8)
ISSN/ISBN: 1098-6596 PMID: 29784848 DOI: 10.1128/aac.00493-18
The in vitro activity of contezolid (MRX-I) against clinical isolates of Mycobacterium tuberculosis was evaluated using a microtiter broth dilution assay. MRX-I was as effective as linezolid (LZD) in vitro MRX-I and LZD were subsequently studied in BALB/c mice infected intranasally with M. tuberculosis Erdman. MRX-I and LZD at 100 mg/kg significantly reduced the bacterial load in lungs compared to the untreated early and late controls.