+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Kinetic time courses of lambda-cyhalothrin metabolites after dermal application of Matador EC 120 in volunteers

Kinetic time courses of lambda-cyhalothrin metabolites after dermal application of Matador EC 120 in volunteers

Toxicology Letters 296: 132-138

A controlled kinetic study was conducted in volunteers dermally exposed to the widely used lambda-cyhalothrin pyrethroid pesticide to document the time courses of relevant biomarkers of exposure, in order to better assess biomonitoring data in workers. Matador® EC120 formulation (120 g/l) was applied on 40 cm2 of the forearm at a 0.25 mg/kg dose of lambda-cyhalothrin and left without occlusion or washing for 6 h. The application site was then washed thoroughly with soap and water. The kinetic time courses of cis-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid (CFMP) and 3-phenoxybenzoic acid (3-PBA) metabolites were determined in plasma and urine up to 84 h post-application. Results show that the fraction of lambda-cyhalothrin absorbed in the body was rapidly cleared following dermal contact. According to CFMP and 3-PBA plasma profiles, calculated mean apparent absorption half-lives (t1/2) were 3 and 7.3 h, respectively, and corresponding mean apparent elimination t1/2 were 11.2 and 7.6 h. These differences suggest some metabolism at the site-of-entry and storage of metabolites by the dermal route. Toxicokinetic parameters calculated from urinary profiles confirm the values of absorption and elimination rates. Metabolites were almost completely excreted over the 84-h period post-application and, on average, 0.12 and 0.08% of the applied lambda-cyhalothrin dose was recovered in the urine as CFMP and 3-PBA, respectively, indicating a low dermal absorption fraction of this pyrethroid. This study showed the potential use of CFMP and 3-PBA biomarkers for the assessment of dermal exposure to lambda-cyhalothrin pyrethroid.

(PDF emailed within 0-6 h: $19.90)

Accession: 065269794

Download citation: RISBibTeXText

PMID: 30120931

DOI: 10.1016/j.toxlet.2018.08.008

Related references

Documenting the kinetic time course of lambda-cyhalothrin metabolites in orally exposed volunteers for the interpretation of biomonitoring data. Toxicology Letters 276: 115-121, 2017

The application of lambda-cyhalothrin in tick control. Experimental and Applied Acarology 52(1): 101-109, 2010

Comparison of the acute toxicity for gamma-cyhalothrin and lambda-cyhalothrin to zebra fish and shrimp. Regulatory Toxicology and Pharmacology 47(2): 184-188, 2006

Comparative aquatic toxicity of the pyrethroid insecticide lambda-cyhalothrin and its resolved isomer gamma-cyhalothrin. Ecotoxicology 18(2): 239-249, 2008

Influence of selected water quality characteristics on the toxicity of lambda-cyhalothrin and gamma-cyhalothrin to Hyalella azteca. Bulletin of Environmental Contamination and Toxicology 79(5): 548-551, 2007

Co-encapsulation of imidacloprid and lambda-cyhalothrin using biocompatible nanocarriers: Characterization and application. Ecotoxicology and Environmental Safety 175: 155-163, 2019

Differential application of lambda-cyhalothrin to control the sandfly Lutzomyia longipalpis. Medical and Veterinary Entomology 11(1): 13-24, 1997

Application of a redox gradostat reactor for assessing rhizosphere microorganism activity on lambda-cyhalothrin. Bulletin of Environmental Contamination and Toxicology 92(3): 347-351, 2014

Exposure and health assessment during application of lambda-cyhalothrin for malaria vector control in Pakistan. Bulletin of the World Health Organization 70(5): 615-619, 1992

Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure. Environmental Science and Pollution Research International 24(6): 5841-5856, 2017

Application of the response surface and desirability design to the Lambda-cyhalothrin degradation using photo-Fenton reaction. Journal of Environmental Management 118: 32-39, 2013

Evaluation of the efficacy of lambda-cyhalothrin applied by three spray application methods for emergency control of Aedes aegypti in Costa Rica. Journal of the American Mosquito Control Association 19(1): 58-62, 2003

Dissipation behavior and dietary risk assessment of lambda-cyhalothrin, thiamethoxam and its metabolite clothianidin in apple after open field application. Regulatory Toxicology and Pharmacology 101: 135-141, 2018

Spinach or amaranth contains highest residue of metalaxyl, fluazifop-P-butyl, chlorpyrifos, and lambda-cyhalothrin on six leaf vegetables upon open field application. Journal of Agricultural and Food Chemistry 61(9): 2039-2044, 2014

Sequential application of lambda-cyhalothrin on cattle with the ElectrodynTM method. Results obtained in Togo in the context of the African animal trypanosomosis control. Revue d' Elevage et de Medecine Veterinaire des Pays Tropicaux 55(3): 189-195, 2002