+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system



Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system



Steroids 2018



The last few decades have revealed increasing complexity and depth to our knowledge of receptor-mediated estrogen signaling. Nuclear estrogen receptors (ERs) ERα and ERβ remain the fundamental dogma, but recent research targeting membrane-bound ERs urges for a more expanded view on ER signaling. ERα and ERβ are also involved in membrane-delineated signaling alongside membrane-specific G protein-coupled estrogen receptor 1 (GPER1), ER-X, and the Gq-coupled membrane ER (Gq-mER). Membrane ERs are responsible for eliciting rapid responses to estrogen signaling, and their importance has been increasingly indicated in central nervous system (CNS) regulation of such functions as reproduction, energy homeostasis, and stress. While the Gq-mER signaling pathway is well characterized, the receptor structure and gene remains uncharacterized, although it is not similar to the nuclear ERα/β. This review will describe the current knowledge of this putative membrane ER and its selective ligand, STX, from its initial characterization in hypothalamic melanocortin circuitry to recent research exploring its role in the CNS outside of the hypothalamus.

(PDF emailed within 0-6 h: $19.90)

Accession: 065308741

Download citation: RISBibTeXText

PMID: 29378226

DOI: 10.1016/j.steroids.2018.01.010


Related references

Membrane-initiated estradiol signaling regulates the central nervous system. Frontiers in Neuroendocrinology 33(4): 329-330, 2013

G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse. Drug and Alcohol Dependence 51(1-2): 73-85, 1998

Molecular cloning and characterization of GPCR/CNS2, a novel G-protein coupled receptor which is highly expressed in the central nervous system. Society for Neuroscience Abstracts 24(1-2): 1091, 1998

Tre1 GPCR signaling orients stem cell divisions in the Drosophila central nervous system. Developmental Cell 22(1): 79-91, 2012

Gq Protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice. Endocrinology 157(9): 3604-3620, 2017

Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A. Diabetes 67(8): 1524-1537, 2018

Molecular cloning of the mouse GPCR/CNS2 gene encoding an orphan G-protein coupled receptor highly expressed in the central nervous system. Society for Neuroscience Abstracts 25(1-2): 183, 1999

Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system. Endocrinology 144(4): 1234-1240, 2003

A variant of estrogen receptor-a, hER-a36: Transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proceedings of the National Academy of Sciences of the United States of America 103(24): 63-8, 2006

Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha36, a variant of ER-alpha. American Journal of Pathology 177(2): 964-973, 2011

Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Annals of the New York Academy of Sciences 1007: 6-16, 2004

Membrane Estrogen Receptors Acting in the Central Nervous System. Immunology Endocrine & Metabolic Agents - Medicinal Chemistry 9(3): 180-190, 2009

Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system (CNS). Journal of Steroid Biochemistry and Molecular Biology 83(1-5): 187-193, 2002

Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system. Journal of Steroid Biochemistry & Molecular Biology 83(1-5): 187-193, December 2002( ), 2003

G protein-coupled receptor (GPCR) kinase 2 regulates agonist-independent Gq/11 signaling from the mouse cytomegalovirus GPCR M33. Journal of Biological Chemistry 281(52): 39796-39805, 2006