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Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology



Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology



Current Oncology Reports 20(5): 37



Mesenchymal chondrosarcoma is a rare but deadly form of chondrosarcoma that typically affects adolescents and young adults. While curative intent is possible for patients with localized disease, few options exist for patients in the unresectable/metastatic setting. Thus, it is imperative to understand the fusion-driven biology of this rare malignant neoplasm so as to lead to the future development of better therapeutics for this disease. This manuscript will briefly review the clinical and pathologic features of mesenchymal chondrosarcoma followed by an appraisal of existing data linked to the fusions, HEY1-NCOA2 and IRF2BP2-CDX1, and the associated downstream pathways.

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Accession: 065310055

Download citation: RISBibTeXText

PMID: 29582189

DOI: 10.1007/s11912-018-0668-z


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