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Mesenteric lymphadenitis as a presenting feature of Whipple's disease: Value of PCR analysis



Mesenteric lymphadenitis as a presenting feature of Whipple's disease: Value of PCR analysis



International Journal of Infectious Diseases 75: 15-17



Whipple's disease (WD) is a rare chronic and systemic infection caused by the ubiquitous actinomycete Tropheryma whipplei. A case of localized infection with mesenteric adenopathy associated with a prolonged unexplained fever is reported herein. Screening by PCR on saliva and stool was positive, and T. whipplei was formally identified by specific PCR on duodenal and mesenteric adenopathy biopsies. Histological analysis did not demonstrate periodic acid-Schiff-positive macrophages or positive T. whipplei immunochemistry in either the duodenal mucosa or mesenteric nodes. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms, and subsequent saliva and stool PCR results were negative.

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Accession: 065310273

Download citation: RISBibTeXText

PMID: 30096359

DOI: 10.1016/j.ijid.2018.08.003


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