+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials

Analytical and Bioanalytical Chemistry 410(24): 6141-6154

Due to the unique physicochemical properties exhibited by materials with nanoscale dimensions, there is currently a continuous increase in the number of engineered nanomaterials (ENMs) used in consumer goods. However, several reports associate ENM exposure to negative health outcomes such as cardiovascular diseases. Therefore, understanding the pathological consequences of ENM exposure represents an important challenge, requiring model systems that can provide mechanistic insights across different levels of ENM-based toxicity. To achieve this, we developed a mussel-inspired 3D microphysiological system (MPS) to measure cardiac contractility in the presence of ENMs. While multiple cardiac MPS have been reported as alternatives to in vivo testing, most systems only partially recapitulate the native extracellular matrix (ECM) structure. Here, we show how adhesive and aligned polydopamine (PDA)/polycaprolactone (PCL) nanofiber can be used to emulate the 3D native ECM environment of the myocardium. Such nanofiber scaffolds can support the formation of anisotropic and contractile muscular tissues. By integrating these fibers in a cardiac MPS, we assessed the effects of TiO2 and Ag nanoparticles on the contractile function of cardiac tissues. We found that these ENMs decrease the contractile function of cardiac tissues through structural damage to tissue architecture. Furthermore, the MPS with embedded sensors herein presents a way to non-invasively monitor the effects of ENM on cardiac tissue contractility at different time points. These results demonstrate the utility of our MPS as an analytical platform for understanding the functional impacts of ENMs while providing a biomimetic microenvironment to in vitro cardiac tissue samples. Graphical Abstract Heart-on-a-chip integrated with mussel-inspired fiber scaffolds for a high-throughput toxicological assessment of engineered nanomaterials.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 065339790

Download citation: RISBibTeXText

PMID: 29744562

DOI: 10.1007/s00216-018-1106-7

Related references

A method to assess the quality of studies that examine the toxicity of engineered nanomaterials. International Journal of Toxicology 29(4): 402-410, 2010

Integrating biologically inspired nanomaterials and table-top stereolithography for 3D printed biomimetic osteochondral scaffolds. Nanoscale 7(33): 14010-14022, 2015

Lab-on-a-chip-based high-throughput screening of the genotoxicity of engineered nanomaterials. Small 10(13): 2721-2734, 2014

A biomimetic mussel-inspired photoelectrochemical biosensing chip for the sensitive detection of CD146. Analyst 140(15): 5019-5022, 2015

The current state of engineered nanomaterials in consumer goods and waste streams: the need to develop nanoproperty-quantifiable sensors for monitoring engineered nanomaterials. Nanotechnology Science and Applications 4: 73-86, 2011

Hierarchical bioceramic scaffolds with 3D-plotted macropores and mussel-inspired surface nanolayers for stimulating osteogenesis. Nanoscale 8(28): 13790-13803, 2016

Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration. Biomaterials Science 6(3): 538-549, 2018

Developmental toxicity of engineered nanomaterials. Toxicology Letters 258: S22-S23, 2016

Predicting of toxicity of engineered nanomaterials. Toxicology Letters 258: S21-S22, 2016

Developmental toxicity of engineered nanomaterials in rodents. Toxicology and Applied Pharmacology 299: 47-52, 2016

Toxicity of engineered nanomaterials: a physicochemical perspective. Journal of Biochemical and Molecular Toxicology 27(1): 50-55, 2013

Toxicity Evaluation of New Engineered Nanomaterials in Zebrafish. Frontiers in Physiology 7: 130, 2016

The concept of bio-corona in modulating the toxicity of engineered nanomaterials (ENM). Toxicology and Applied Pharmacology 299: 53-57, 2016

Toxicity assessment of engineered nanomaterials: resolving the challenges. Journal of Biomedical Nanotechnology 7(1): 6-7, 2011

Toxicity of engineered nanomaterials mediated by nano-bio-eco interactions. Journal of Environmental Science and Health. Part C Environmental Carcinogenesis and Ecotoxicology Reviews 36(1): 21-42, 2018