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Mutation and Epistasis in Influenza Virus Evolution

Mutation and Epistasis in Influenza Virus Evolution

Viruses 10(8)

Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus's capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses.

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Accession: 065340022

Download citation: RISBibTeXText

PMID: 30081492

DOI: 10.3390/v10080407

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