+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria

Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria

Plos Pathogens 14(5): E1007026

Innate immune recognition is classically mediated by the interaction of host pattern-recognition receptors and pathogen-associated molecular patterns; this triggers a series of downstream signaling events that facilitate killing and elimination of invading pathogens. In this report, we provide the first evidence that peroxidasin (PXDN; also known as vascular peroxidase-1) directly binds to gram-negative bacteria and mediates bactericidal activity, thus, contributing to lung host defense. PXDN contains five leucine-rich repeats and four immunoglobulin domains, which allows for its interaction with lipopolysaccharide, a membrane component of gram-negative bacteria. Bactericidal activity of PXDN is mediated via its capacity to generate hypohalous acids. Deficiency of PXDN results in a failure to eradicate Pseudomonas aeruginosa and increased mortality in a murine model of Pseudomonas lung infection. These observations indicate that PXDN mediates previously unrecognized host defense functions against gram-negative bacterial pathogens.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 065399692

Download citation: RISBibTeXText

PMID: 29775486

DOI: 10.1371/journal.ppat.1007026

Related references

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. Plos Pathogens 10(9): E1004368, 2014

Mast cells as critical effectors of host immune defense against Gram-negative bacteria. Current Medicinal Chemistry 19(10): 1432-1442, 2012

Mast Cells as Critical Effectors of Host Immune Defense against Gram-negative Bacteria. Current Medicinal Chemistry 19(10): 1432-1442, 2012

Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin. Current Opinion in Immunology 5(1): 103-107, 1993

Killing of gram-negative bacteria by neutrophils: role of O2-independent system in intracellular killing and evidence of O2-dependent extracellular killing. Advances in Experimental Medicine and Biology 184: 35-50, 1985

Critical role for macrophage migration inhibitory factor in host defense against gram-negative bacteria. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 40: 243, 2000

The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiology 187(3-5): 417-429, 1993

Rough strains of gram negative bacteria differ in their sensitivity to c1q or mannan binding protein mediated killing. Complement & Inflammation 8(3-4): 141-142, 1991

Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infection and Immunity 73(1): 532-545, 2005

Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine. Frontiers in Cellular and Infection Microbiology 5: 105, 2015

Lipopolysaccharide-binding protein of Bombyx mori participates in a hemocyte-mediated defense reaction against gram-negative bacteria. Journal of insect physiology 45(9): 853-859, 1999

Comparison of killing of gram-negative and gram-positive bacteria by pure singlet oxygen. Journal of Bacteriology 171(4): 2188-2194, 1989

Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice. Shock 25(4): 414-419, 2006

Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. Bmc Microbiology 18(1): 54, 2018

Distinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteria. Journal of Biological Chemistry 276(49): 45840-7, 2001