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Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance



Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance



Diabetes and Metabolism 44(6): 488-492



To assess circulating fetuin-B concentrations in subjects with different degrees of glucose tolerance and to analyze the association of fetuin-B concentrations with insulin resistance and the first phase of glucose-stimulated insulin secretion. Plasma fetuin-B concentrations were analyzed in 149 subjects with normal glucose tolerance (NGT, n=54), impaired glucose regulation (preDM, n=42) and newly diagnosed type-2 diabetes mellitus (nT2DM, n=53). Intravenous glucose tolerance tests (IVGTTs) and biochemical parameters were also assessed in all participants. Plasma fetuin-B concentrations were significantly higher in nT2DM patients compared with NGT and preDM subjects (both P<0.001) and positively correlated with FPG, 2hPG, HOMA-IR, HbA1c, hsCRP, FINS and TG (P<0.05), but negatively correlated with AIR, AUC, GDI and fasting Belfiore index (P<0.01). After adjusting for age and gender, all correlations remained statistically significant (P<0.05). Multivariate logistic regression analysis revealed that plasma fetuin-B concentrations were significantly correlated with nT2DM after controlling for age, gender, BMI, WHR, blood pressure and lipid profiles. Patients with nT2DM have significantly higher concentrations of plasma fetuin-B compared with NGT subjects and plasma fetuin-B is strongly associated with glucose and lipid metabolism, chronic inflammation and first-phase glucose-stimulated insulin secretion and insulin resistance.

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Accession: 065411066

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PMID: 29514765

DOI: 10.1016/j.diabet.2018.02.003


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