+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pre-protective effects of dietary chitosan supplementation against oxidative stress induced by diquat in weaned piglets



Pre-protective effects of dietary chitosan supplementation against oxidative stress induced by diquat in weaned piglets



Cell Stress and Chaperones 23(4): 703-710



The protective effects of chitosan (CS) supplementations on oxidative stress induced by diquat in weaned piglets were investigated. A total of 36 crossbreed piglets with an average live body weight (BW) of 8.80 ± 0.53 kg were weaned at 28 ± 2 days and randomly divided into six dietary treatments (n = 6): control (basal diet), negative control (10 mg diquat/kg BW injected to piglets fed with basal diet), and basal diet treatments containing either 250, 500, 1000, or 2000 mg/kg of CS administered to piglets injected with 10 mg diquat/kg BW. The experiment conducted for 21 days which consisted of pre-starter period (14 days) and starter period (7 days). BW, feed intake, and fecal consistency were monitored. Blood samples were collected to determine antioxidative and immune parameters. CS supplementation improved the growth performance and decreased fecal score of piglets from days 1 to 14. Diquat also induced oxidative stress and inflammatory responses by decreasing the activities of antioxidant and regulating cytokines. But dietary CS alleviated these negative effects induced by diquat that showed decreasing serum concentrations of pro-inflammatory cytokines but increasing activities of antioxidant enzymes and anti-inflammatory cytokines. Results indicated that CS attenuated the oxidative stress of piglets caused by diquat injection.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065428770

Download citation: RISBibTeXText

PMID: 29455342

DOI: 10.1007/s12192-018-0882-5


Related references

Protective effects of dietary arginine supplementation against oxidative stress in weaned piglets. British Journal of Nutrition 109(12): 2253-2260, 2013

Arginine metabolism and its protective effects on intestinal health and functions in weaned piglets under oxidative stress induced by diquat. British Journal of Nutrition 117(11): 1495-1502, 2017

Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets. Plos one 10(4): E0122893, 2015

The effect of dietary tryptophan levels on oxidative stress of liver induced by diquat in weaned piglets. Journal of Animal Science and Biotechnology 5(1): 49, 2014

Effects of dietary supplementation of chitosan on humoral and cellular immune function in weaned piglets. Animal Feed Science and Technology 186(3-4): 204-208, 2013

Dietary supplementation with L-glutamate and L-aspartate alleviates oxidative stress in weaned piglets challenged with hydrogen peroxide. Amino Acids 48(1): 53-64, 2016

Effects of Dietary Serine Supplementation on Intestinal Integrity, Inflammation and Oxidative Status in Early-Weaned Piglets. Cellular Physiology and Biochemistry 48(3): 993, 2018

Dietary Saccharomyces cerevisiae Cell Wall Extract Supplementation Alleviates Oxidative Stress and Modulates Serum Amino Acids Profiles in Weaned Piglets. Oxidative Medicine and Cellular Longevity 2017: 3967439, 2017

Dietary supplementation with Lactobacillus fermentum I5007 improves the anti-oxidative activity of weanling piglets challenged with diquat. Journal of Applied Microbiology 114(6): 1582-1591, 2013

Dietary chitosan supplementation attenuates isoprenaline-induced oxidative stress in rat myocardium. International Journal of Biological Macromolecules 51(5): 783-787, 2012

Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Food and Chemical Toxicology 48(2): 764-770, 2010

Effect of Dietary Supplementation of Galacto-mannan-oligosaccharides and Chitosan on Performance and Serum Immune Parameters of 28-day Weaned Piglets Challenged with Pathogenic E.coli. Journal of Applied Animal Research 36(2): 207-211, 2009

Dietary Verbascoside Influences Gut Morphology and the Expression of α-Transducin and α-Gustducin in the Small Intestine of Weaned Piglets Exposed to n-6 Polyunsaturated Fatty Acids-Induced Oxidative Stress. Animals 9(1):, 2019

Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets. Domestic Animal Endocrinology 28(4): 430-441, 2005

Natural vitamin E d-?-tocopherol supplementation in drinking water prevents oxidative stress in weaned piglets. Livestock Science 145(1-3): 55-62, 2012