+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic factors for post-recurrence survival in patients with completely resected Stage III (N2) non-small-cell lung cancer



Prognostic factors for post-recurrence survival in patients with completely resected Stage III (N2) non-small-cell lung cancer



European Journal of Cardio-Thoracic Surgery 54(3): 554-559



The aim of this study was to investigate the prognostic factors for post-recurrence survival (PRS) in patients with completely resected Stage III (N2) non-small-cell lung cancer. A number of clinicopathological factors were evaluated to identify the prognostic factors for recurrence-free survival using Cox proportional hazards models in 245 patients who underwent complete resection of pathological Stage III (N2) non-small-cell lung cancer. Additional post-recurrence data were evaluated, including the presence of symptoms of recurrence, the recurrence pattern, the treatment modality and the recurrence-free interval (RFI). The prognostic effects of clinicopathological factors before recurrence and the additional post-recurrence data on PRS were analysed. A total of 124 patients experienced recurrence during a median follow-up period of 39.8 months. Twenty-one patients were symptomatic at the time of initial recurrence, and the mean RFI was 14.0 months. Loco-regional recurrence was observed in 38 (31%) patients, distant metastasis in 33 (27%) patients and both in 53 (42%) patients. The initial treatment modality was surgery in 17 (14%) patients, chemotherapy in 66 (53%) patients, radiotherapy in 17 (14%) patients and chemoradiotherapy in 18 (15%) patients. The median duration of PRS was 30.5 months (range 1-109 months), and the 1-, 3- and 5-year PRS rates were 72%, 43% and 23%, respectively. A shorter RFI and radiotherapy for the treatment of recurrence were found to be independent prognostic factors for PRS in the multivariable analysis. The prognostic factors for recurrence-free survival were not associated with PRS, and a shorter RFI and radiotherapy for the treatment of recurrence were found to be negative prognostic factors for PRS.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065438076

Download citation: RISBibTeXText

PMID: 29490049

DOI: 10.1093/ejcts/ezy063


Related references

P1.08-066 Prognostic Factors of Post-Recurrence Survival in Patients with Completely Resected Stage Iii-N2 Non-Small Cell Lung Cancer. Journal of Thoracic Oncology 12(1): S771-S772, 2017

Prognostic factors for post-recurrence survival in patients with completely resected Stage I non-small-cell lung cancer. European Journal of Cardio-Thoracic Surgery 45(2): 262-267, 2014

Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence. Thorax 64(3): 192-196, 2009

Prognostic Factors for Post Recurrence Survival in Resected Pathological Stage I Non-small Cell Lung Cancer. Yonago Acta Medica 60(4): 213-219, 2017

Prognostic factors and the significance of treatment after recurrence in completely resected stage I non-small cell lung cancer. Chest 143(6): 1626-1634, 2013

Prognostic factors of postrecurrence survival in completely resected stage I non-small cell lung cancer with distant metastasis. Thorax 65(3): 241-245, 2010

Predictors of post-recurrence survival in patients with non-small-cell lung cancer initially completely resected. Interactive Cardiovascular and Thoracic Surgery 21(1): 14-20, 2015

Prognostic factors in patients with postoperative brain recurrence from completely resected non-small cell lung cancer. Thoracic Cancer 6(1): 38-42, 2015

Time trends of overall survival and survival after recurrence in completely resected stage I non-small cell lung cancer. Journal of Thoracic Oncology 7(2): 397-405, 2012

The prognostic impact of preoperative PET-CT on postoperative recurrence for completely resected stage I non-small cell lung cancer. Zhonghua Wai Ke Za Zhi 53(7): 502-507, 2015

Prognostic factors of tumor recurrence in completely resected non-small cell lung cancer. Cancer Management and Research 5: 77-84, 2013

The prognostic value of ERCC1 and RRM1 gene expression in completely resected non-small cell lung cancer: tumor recurrence and overall survival. Cancer Management and Research 5: 327-336, 2013

Biological prognostic factors for early stage completely resected non-small cell lung cancer. Journal of Surgical Oncology 74(1): 53-60, 2000

Completely resected N1 non-small cell lung cancer: factors affecting recurrence and long-term survival. Journal of Thoracic and Cardiovascular Surgery 132(3): 499-506, 2006

Post-operative adjuvant thoracic radiotherapy for patients with completely resected non-small cell lung cancer with nodal involvement: outcome and prognostic factors. British Journal of Radiology 77(913): 43-48, 2004