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Recent Advances in the Development of Indazole-based Anticancer Agents



Recent Advances in the Development of Indazole-based Anticancer Agents



Chemmedchem 13(15): 1490-1507



Cancer is one of the leading causes of human mortality globally; therefore, intensive efforts have been made to seek new active drugs with improved anticancer efficacy. Indazole-containing derivatives are endowed with a broad range of biological properties, including anti-inflammatory, antimicrobial, anti-HIV, antihypertensive, and anticancer activities. In recent years, the development of anticancer drugs has given rise to a wide range of indazole derivatives, some of which exhibit outstanding activity against various tumor types. The aim of this review is to outline recent developments concerning the anticancer activity of indazole derivatives, as well as to summarize the design strategies and structure-activity relationships of these compounds.

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Accession: 065462645

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PMID: 29863292

DOI: 10.1002/cmdc.201800253


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