+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Significance of hepatic resection and adjuvant hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombus in the first branch of portal vein and the main portal trunk: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery



Significance of hepatic resection and adjuvant hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombus in the first branch of portal vein and the main portal trunk: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery



Journal of Hepato-Biliary-Pancreatic Sciences 25(9): 395-402



The prognosis of hepatocellular carcinoma (HCC) with tumor thrombus in the major portal vein (PV) is extremely poor. The purpose of this study was to clarify the impact of hepatic resection for HCC with tumor thrombus in the major PV. Four hundred patients undergoing macroscopic curative resection for HCC involving the first branch or trunk of the PV between 2001 and 2010 at the 22 institutions were enrolled. We examined the effect of adjuvant hepatic arterial infusion chemotherapy (HAIC) on prognosis and validated the prognostic index consisting of ascites, prothrombin activity, and maximal tumor diameter. Median survival time (MST) and 5-year overall survival rate were 21.5 months and 25.7%. MST of HAIC group was longer than that of non-HAIC group (28.1 months vs. 18.7 months, P = 0.0024). Significant prognostic factors for overall survival were PIVKA-II, tumor diameter, and adjuvant HAIC. MST for patients with prognostic index 0, 1, 2, and 3 was 39.0, 21.1, 18.9, and 5.7 months, respectively (P = 0.005). Macroscopic curative resection with adjuvant HAIC might provide better survival outcome. Furthermore, the prognostic index was useful to select adequate treatment modalities for patients with HCC with tumor thrombosis in the major PV.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065512962

Download citation: RISBibTeXText

PMID: 30091239

DOI: 10.1002/jhbp.574


Related references

A case of hepatocellular carcinoma with tumor thrombi in the first branch of the portal vein and hepatic vein trunks treated by transcatheter hepatic arterial chemoembolization and hepatic arterial infusion chemotherapy--two years and six months follow-up. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 32(5): 667-670, 2005

A case of curative resection for advanced hepatocellular carcinoma with portal vein tumor thrombus after hepatic arterial infusion chemotherapy. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 39(12): 1991-1993, 2012

A successful case of more than 5 years of disease free survival in hepatocellular carcinoma with tumor thrombus to the right main branch of portal vein after repeated hepatic resection following transhepatic arterial embolization (TAE). Gan to Kagaku Ryoho. Cancer & ChemoTherapy 32(11): 1821-1823, 2005

Hepatic arterial infusion chemotherapy A novel treatment for unresectable hepatocellular carcinoma involving tumor thrombus in the main portal trunk. Hepatology 24(4 Part 2): 585A, 1996

Sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus. Anticancer Research 35(4): 2269-2277, 2015

Hepatic arterial infusion chemotherapy using 5-FU and CDDP in advanced hepatocellular carcinoma involving portal vein tumor thrombus. Hepatology 28(4 Part 2): 229A, 1998

Hepatic Arterial Infusion Chemotherapy: A Potential Therapeutic Option for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus. Liver Cancer 7(2): 209-210, 2018

Significance of trans-hepatic arterial chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus. Oncology Reports 20(2): 353-357, 2008

Clinical outcome of esophageal varices after hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus. Hepatology Research 41(11): 1046-1056, 2011

Pathological complete remission of advanced hepatocellular carcinoma with main portal vein tumor thrombosis by hepatic arterial infusion chemotherapy. Gut and Liver 4(2): 266-269, 2010

Transarterial embolization and low-dose continuous hepatic arterial infusion chemotherapy with oxaliplatin and raltitrexed for hepatocellular carcinoma with major portal vein tumor thrombus. World Journal of Gastroenterology 24(23): 2501-2507, 2018

The effect of sorafenib and intermittent hepatic arterial infusion chemotherapy using cisplatin for advanced hepatocellular carcinoma with portal vein tumor thrombus--a pilot study. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(12): 2679-2682, 2010

Recurrence and survivals following hepatic resection for hepatocellular carcinoma with major portal/hepatic vein tumor thrombus. Hepatology Research 44(7): 761-768, 2014

Hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombosis. World Journal of Gastroenterology 9(12): 2666-2670, 2003

Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis. World Journal of Gastroenterology 19(29): 4679-4688, 2013