Section 66
Chapter 65,555

Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

Chen, B-Zhi.; Zhi, M-Ling.; Wang, C-Xin.; Chu, X-Qiang.; Shen, Z-Liang.; Loh, T-Peng.

Organic Letters 20(7): 1902-1905


ISSN/ISBN: 1523-7060
PMID: 29527900
DOI: 10.1021/acs.orglett.8b00441
Accession: 065554206

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An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

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