+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The effect of nitrous oxide in comparison to oxygen combined with fentanyl on the hospitalization time and pain reduction in renal colic patients at emergency department



The effect of nitrous oxide in comparison to oxygen combined with fentanyl on the hospitalization time and pain reduction in renal colic patients at emergency department



Journal of Research in Medical Sciences 23: 18



Renal colic is a painful medical emergency, needs urgent intervention to reduce pain. Nonsteroidal anti-inflammatory drugs, opioids, and entonox are pain-relieving agents. This study was aimed to compare fentanyl + entonox (nitrous oxide + O2) versus fentanyl + oxygen. One hundred and twenty patients with acute renal colic presenting to the emergency department were enrolled. First, 50 μg fentanyl was infused for all patients. Then, patients divided into two groups receiving masks of entonox and oxygen, respectively. Quantitative measurement of pain was performed by visual analog scale, before the intervention, after 3, 5, 10, and 30 min of that. If the pain was not relieved after 30 min, 50 μg fentanyl was infused. If the pain was still continued, ketorolac and ketamine were used. Hospitalization duration and severity of pain at specified times were compared between patients in two groups. The mean (standard deviation) time of hospitalization was 211 (59) and 236 (61) min in fentanyl + entonox and fentanyl + O2 groups, respectively (P = 0.024). The decrease in pain severity after 10 and 30 min in fentanyl + entonox group were significantly greater than fentanyl + O2 group (P = 0.002 and 0.001, respectively). Mean (standard error) of needed time for renal colic pain to get better was 11.27 (1.23) and 20.47 (1.71) min in fentanyl + entonox and fentanyl + O2 groups, respectively (P < 0.001). Proportion of patients relief from pain in fentanyl + entonox in the second, third, and fourth measurements were significantly more than fentanyl + O2 group (P = 0.036, P < 0.001, and P < 0.001, respectively). Entonox is more effective to decrease the duration of hospitalization and reduction of pain than O2 in renal colic patients.

(PDF emailed within 1 workday: $29.90)

Accession: 065579380

Download citation: RISBibTeXText

PMID: 29531570


Related references

Multicenter, triple-blind randomized placebo controlled trial of adjuvant nitrous oxide 50% in oxygen 50%: efficacy for reducing pain and increasing satisfaction in patients treated for renal colic in the emergency department. Emergencias 28(5): 305-312, 2018

Use of combined transmucosal fentanyl, nitrous oxide, and hematoma block for fracture reduction in a pediatric emergency department. Pediatric Emergency Care 28(7): 676-679, 2013

Nitrous Oxide 70% for Procedural Analgosedation in a Pediatric Emergency Department With or Without Intranasal Fentanyl?: Analgesic Efficacy and Adverse Events if Combined With Intranasal Fentanyl. Pediatric Emergency Care 2017, 2017

Comparison of IV dexketoprofen trometamol, fentanyl, and paracetamol in the treatment of renal colic in the ED: A randomized controlled trial. American Journal of Emergency Medicine 36(4): 571-576, 2017

Comparing the analgesic effect of intravenous acetaminophen and morphine on patients with renal colic pain referring to the emergency department: A randomized controlled trial. Journal of Research in Medical Sciences 18(9): 772-776, 2014

Effect of anaesthesia with nitrous oxide in oxygen and fentanyl on renal function in the artificially ventilated dog. British Journal of Anaesthesia 52(3): 343-348, 1980

Value of premixed nitrous-oxide-and-oxygen mixtures in the relief of post-operative pain. Double-blind trial of 25% nitrous oxide in oxygen, 15% nitrous oxide in oxygen, and oxygen. Brit Med J 2(5420): 1303-1305, 1964

Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department: a 2.5-year study. Bone and Joint Journal 98-B(1): 131-136, 2016

A randomized comparison of nitrous oxide plus hematoma block versus ketamine plus midazolam for emergency department forearm fracture reduction in children. Pediatrics 118(4): E1078-E1086, 2006

A standardized pain management protocol improves timeliness of analgesia among emergency department patients with renal colic. Quality Management in Health Care 20(1): 30-36, 2011

Comparison of sufentanil nitrous oxide vs. fentanyl nitrous oxide in patients undergoing general surgery a blind study. Anesthesiology 69(3A): A213, 1988

Comparison of sufentanil nitrous oxide and fentanyl nitrous oxide in patients without cardiac disease undergoing general surgery. Anesthesiology 66(2): 130-135, 1987

Value of Premixed Nitrous-Oxide-And-Oxygen Mixtures in the Relief of Post-Operative Pain. Double-Blind Trial of 25 Percent Nitrous Oxide in Oxygen, 15 Percent Nitrous Oxide in Oxygen, and Oxygen. British Medical Journal 2(5420): 1303-1305, 1964

Comparison of anesthesia by halothane nitrous oxide enflurane nitrous oxide morphine nitrous oxide and high dose fentanyl diazepam for coronary artery bypass surgery hemodynamic and hormonal study. Journal of Kyoto Prefectural University of Medicine 97(3): 391-400, 1988

Heart rate and rhythm following an edrophonium atropine mixture for antagonism of neuromuscular blockade during fentanyl nitrous oxide oxygen or isoflurane nitrous oxide oxygen anesthesia. Anesthesiology 67(4): 561-565, 1987