+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The preoperative HbA1c level is an independent prognostic factor for the postoperative survival after resection of non-small cell lung cancer in elderly patients



The preoperative HbA1c level is an independent prognostic factor for the postoperative survival after resection of non-small cell lung cancer in elderly patients



Surgery Today 48(5): 517-524



The aim of this study was to investigate the influence of a history of diabetes mellitus (DM) and the glycated hemoglobin (HbA1c) level on the survival in patients who underwent complete resection for non-small cell lung cancer (NSCLC). Of the patients who underwent complete resection for NSCLC between 2007 and 2015, 468 were classified into DM (who were currently taking medication for DM) and no DM groups as well as into high HbA1c (≥ 6.5) and normal HbA1c (< 6.5) groups. The overall survival (OS) did not differ significantly between either pair of groups. Among the elderly patients, the OS did not differ significantly between the DM and no DM groups, but was significantly higher in the normal-HbA1c group than in the high-HbA1c group (5-year survival rate: 84.7 versus 37.2%, respectively, p < 0.01). In the elderly patients, non-adenocarcinoma histology, advanced stage, a high Charlson comorbidity index, and a high preoperative HbA1c level were found to be independent risk factors for the OS. We revealed that a high preoperative HbA1c level was associated with a poor OS in elderly patients who underwent complete resection for NSCLC. This suggests that it is necessary to achieve diabetic control prior to complete resection in NSCLC patients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065603743

Download citation: RISBibTeXText

PMID: 29222669

DOI: 10.1007/s00595-017-1612-9


Related references

Preoperative plasma D-dimer level is an independent prognostic factor in patients with completely resected non-small cell lung cancer. Surgery Today 45(1): 63-67, 2015

The advanced lung cancer inflammation index is an independent prognostic factor after surgical resection in patients with non-small-cell lung cancer. Interactive Cardiovascular and Thoracic Surgery 26(2): 288-292, 2018

Tumor-stroma ratio (TSR) in non-small cell lung cancer (NSCLC) patients after lung resection is a prognostic factor for survival. Journal of Thoracic Disease 9(10): 4017-4026, 2017

High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients. British Journal of Cancer 93(1): 137-143, 2005

Preoperative total serum cholesterol as a prognostic factor for survival in patients with resectable non-small-cell lung cancer. Wiener Klinische Wochenschrift 121(9-10): 314-317, 2009

P084 Musashi-2 Expression Is an Prognostic Factor for Postoperative Survival in Patients with Non-Small Cell Lung Cancer. Journal of Thoracic Oncology 13(12): S1078-S1079, 2018

Establishment of tumor cell lines as an independent prognostic factor for survival time in patients with small-cell lung cancer. Journal of the National Cancer Institute 83(23): 1743-1748, 1991

Serum level of osteopontin as a prognostic factor in patients who underwent surgical resection for non-small-cell lung cancer. Clinical Lung Cancer 14(3): 288-294, 2013

Decrease of interleukin-2 secretion is a new independent prognostic factor associated with poor survival in patients with small-cell lung cancer. Annals of Oncology 8(5): 457-461, 1997

Postoperative Serum CEA Level is a More Significant Prognostic Factor than Post/Preoperative Serum CEA Ratio in Non-small Cell Cancer Patients. Asian Pacific Journal of Cancer Prevention 16(17): 7809-7812, 2015

Pretreatment quality of life is an independent prognostic factor for overall survival in patients with advanced stage non-small cell lung cancer. Journal of Thoracic Oncology 4(9): 1075-1082, 2009

Preoperative lymphocyte count is an independent prognostic factor in node-negative non-small cell lung cancer. Lung Cancer 75(2): 223-227, 2012

Increasing preoperative neutrophil to lymphocyte ratio: An independent predictor of adverse survival after pulmonary resection of non-small cell lung cancer. Journal of Clinical Oncology 26(15_Suppl): 22090-22090, 2016

Pulmonary resection in patients aged 80 years or over with clinical stage I non-small cell lung cancer: prognostic factors for overall survival and risk factors for postoperative complications. Journal of Thoracic Oncology 4(10): 1247-1253, 2009

Alpha-1-acid glycoprotein as an independent predictor for treatment effects and a prognostic factor of survival in patients with non-small cell lung cancer treated with docetaxel. Clinical Cancer Research 9(3): 1077-1082, 2003