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Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

Chemical Communications 54(15): 1849-1852

BODIPY derivative, SF-1, exclusively shows a fluorescence ON response to HOCl and images endogenously generated HOCl in RAW 264.7 macrophages. Widefield and super resolution structured illumination microscopy images confirm localization in the Golgi complex and lysosomes, and hence specifically detects HOCl generated in these organelles. SF-1 is compatible with 3D-SIM imaging of individual cells.

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Accession: 065631834

Download citation: RISBibTeXText

PMID: 29384535

DOI: 10.1039/c7cc09433g

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