+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Are Women with a History of Low PAPP-A at Risk for Adverse Perinatal Outcomes in a Subsequent Pregnancy?



Are Women with a History of Low PAPP-A at Risk for Adverse Perinatal Outcomes in a Subsequent Pregnancy?



American Journal of Perinatology 36(6): 647-652



 To determine if patients with a history of low pregnancy-associated plasma protein A (PAPP-A) in an initial pregnancy are at higher risk for adverse obstetric outcomes in a subsequent pregnancy.  This was a retrospective cohort study in patients who underwent first trimester screening for PAPP-A in two consecutive pregnancies. Two groups were examined: patients who had low PAPP-A in the first pregnancy followed by normal PAPP-A in the second pregnancy and patients who had recurrent low PAPP-A. Maternal and neonatal outcomes were compared between the groups, with the primary outcome being intrauterine growth restriction (IUGR) or preeclampsia.  A total of 124 patients were included, representing 248 pregnancies. Ninety-two (74.2%) patients had normal PAPP-A in the second pregnancy, and 32 (12.9%) patients had recurrent low PAPP-A. Patients with recurrent low PAPP-A had a higher rate of IUGR or preeclampsia compared with patients with normal PAPP-A in the second pregnancy but this was not significantly different (12.5 vs. 10.9%, p = 0.51). There were no significant differences for all other outcomes.  Among patients with a history of low PAPP-A, patients with normal PAPP-A in the subsequent pregnancy have a similar risk of adverse neonatal outcomes compared with patients with recurrent low PAPP-A.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065700075

Download citation: RISBibTeXText

PMID: 30336500

DOI: 10.1055/s-0038-1673651


Related references

Association of previous severe low birth weight with adverse perinatal outcomes in a subsequent pregnancy among HIV-prevalent urban African women. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 136(2): 188-194, 2017

Is pregnancy associated plasma protein-A (PAPP-A) a marker for adverse perinatal outcomes in preterm isolated oligohydramnios cases?. Taiwanese Journal of Obstetrics and Gynecology 57(1): 71-75, 2018

History of fetal loss and other adverse pregnancy outcomes in relation to subsequent risk of preterm delivery. Maternal and Child Health Journal 7(1): 53-58, 2003

Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus. Lupus Science and Medicine 1(1): E000024, 2014

Prevalence of antiphospholipid antibodies and risk of subsequent adverse obstetric outcomes in women with prior pregnancy loss. Journal of Reproductive Immunology 107: 59-63, 2015

Low levels of maternal serum PAPP-A in early pregnancy and the risk of adverse outcomes. Prenatal Diagnosis 28(11): 1029-1036, 2008

Use of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and PROK1/PAPP-A ratio to predict adverse pregnancy outcomes in the first trimester: a prospective study. Journal of Maternal-Fetal and Neonatal Medicine 31(20): 2685-2692, 2018

The association between stillbirth in the first pregnancy and subsequent adverse perinatal outcomes. American Journal of Obstetrics and Gynecology 201(4): 378.E1-6, 2009

Impact of interpregnancy interval on the subsequent risk of adverse perinatal outcomes. Journal of Obstetrics and Gynaecology Research 41(11): 1744-1751, 2015

Combining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model. Bmc Pregnancy and Childbirth 17(1): 10, 2017

Adequate prenatal care reduces the risk of adverse pregnancy outcomes in women with history of infertility: a nationwide population-based study. Plos one 8(12): E84237, 2013

Use of antihypertensive medications in pregnancy and the risk of adverse perinatal outcomes: McMaster Outcome Study of Hypertension In Pregnancy 2 (MOS HIP 2). Bmc Pregnancy and Childbirth 1(1): 6, 2001

Medical Abortion and the Risk of Subsequent Adverse Pregnancy Outcomes. Obstetrical & Gynecological Survey 62(12): 793-794, 2007

Medical abortion and the risk of subsequent adverse pregnancy outcomes. New England Journal of Medicine 357(7): 648-653, 2007

Adverse pregnancy outcomes and risk of subsequent rheumatoid arthritis. Arthritis and Rheumatology 66(3): 508-512, 2014