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Can a Charged Surfactant Unfold an Uncharged Protein?



Can a Charged Surfactant Unfold an Uncharged Protein?



Biophysical Journal 115(11): 2081-2086



Does sodium dodecyl sulfate (SDS) denature proteins through electrostatic SDS-protein interactions? We show that a protein completely lacking charged side chains is unfolded by SDS in a manner similar to charged proteins, revealing that formal protein charges are not required for SDS-induced protein unfolding or binding.

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Accession: 065717125

Download citation: RISBibTeXText

PMID: 30447995

DOI: 10.1016/j.bpj.2018.10.022


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