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HIPEC with oxaliplatin for colorectal peritoneal metastasis: The end of the road?

HIPEC with oxaliplatin for colorectal peritoneal metastasis: The end of the road?

European Journal of Surgical Oncology 45(3): 400-402

In patients with colorectal peritoneal metastases (PM), the use of cytoreductive surgery (CRS) and HIPEC with oxaliplatin (OX) is increasingly used. The results of the recently reported randomized Prodige 7 trial failed to show a difference in overall survival between patients undergoing CRS alone versus CRS combined with HIPEC using high dose OX. The trial was not designed or powered, however, to detect a potentially clinically meaningful benefit in locoregional disease control. Here, I address some potential explanations for the lack of benefit in the Prodige 7 trial, including OX efficacy issues, adverse effects of intraperitoneal high dose glucose, and potential drawbacks of the use of hyperthermia.

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Accession: 065803557

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PMID: 30392745

DOI: 10.1016/j.ejso.2018.10.542

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