EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

In situ phase transition of microemulsions for parenteral injection yielding lyotropic liquid crystalline carriers of the antitumor drug bufalin


In situ phase transition of microemulsions for parenteral injection yielding lyotropic liquid crystalline carriers of the antitumor drug bufalin



Colloids and Surfaces. B Biointerfaces 173: 217-225



ISSN/ISBN: 0927-7765

PMID: 30296646

DOI: 10.1016/j.colsurfb.2018.09.023

In this work, we used the small angle X-ray scattering (SAXS) method for controlled preparation of in situ forming sustained-release carriers for the antitumor drug bufalin (BUF), which has very poor solubility and a considerable cardiotoxicity in a non-encapsulated state. To that aim, we exploited the pseudo-ternary phase diagram of an oil(O)/surfactant(S)/water(W) system containing medium chain capric/caprylic triglycerides (MCT) and a co-surfactant blend of Macrogol (15)-hydroxystearate (Solutol HS 15) and sorbitan monooleate (Span 80). Two compositions with different oil contents (sample B and C) were selected from the microemulsion region of the phase diagram in order to study the effect of the aqueous environment on their structural behavior. A phase transition from a microemulsion (ME) to a liquid crystalline phase (LC) was established by SAXS upon progressive dilution. The drug bufalin (BUF) was encapsulated in the microemulsions with low viscosity, whereas the release of the drug occurred from the in situ generated lamellar liquid crystalline structures. The formulations were characterized by SAXS, dynamic light scattering (DLS), cryogenic transmission electron microscopy (Cryo-TEM), rheology, drug loading and encapsulation efficiency, and in vitro release profiles. A correlation was suggested between the structures of the in situ phase-transition formed LCME formulations, the differences in their viscosities and drug release profiles. The performed cytotoxicity, cell apoptosis and pharmacokinetic experiments showed an enhanced bioavailability of BUF after encapsulation. These results suggest potential clinical applications for the obtained safe in situ phase-transition sustained-release formulations of BUF.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065820055

Download citation: RISBibTeXText

Related references

Production and characterization of coated lyotropic liquid crystalline colloidal drug carriers. Abstracts of Papers American Chemical Society 223(1-2): COLL 226, 2002

Kinetics of phase transition in lyotropic liquid crystalline polymers. Polymer International 32(4): 339-342, 1993

In-situ phase transition from microemulsion to liquid crystal with the potential of prolonged parenteral drug delivery. International Journal of Pharmaceutics 431(1-2): 130-137, 2012

Kinetics of phase transition in a lyotropic liquid-crystalline polymer system. Ilcc 2000 International Liquid Crystal Conference 365: 387-395, 2001

Selective Sequence for the Peptide-Triggered Phase Transition of Lyotropic Liquid-Crystalline Structures. Langmuir: the Acs Journal of Surfaces and Colloids 32(20): 5155-5161, 2016

Lyotropic liquid-crystalline phase of oligo(ethylene oxide) surfactant/transition metal salt and the synthesis of mesostructured cadmium sulfide. Chemistry of Materials 15(14): 2711-2717, 2003

Synthesis and characterization of a combined main-chain/side-chain liquid-crystalline polymer exhibiting both thermotropic and lyotropic characteristics and its lyotropic phase behavior. Macromolecules 38(23): 9602-9609, 2005

Nonionic diethanolamide amphiphiles with saturated hydrocarbon chains: neat crystalline and lyotropic liquid crystalline phase behavior. Journal of Colloid and Interface Science 385(1): 87-95, 2012

Studies of the crystalline-liquid crystalline phase transition of lipid model membranes. I. Use of spin labels and optical probes as indicators of the phase transition. Journal of the American Chemical Society 94(13): 4482-4491, 1972

Studies of the crystalline liquid crystalline phase transition of lipid model membranes part 1 use of spin labels and optical probes as indicators of the phase transition. Journal Of The American Chemical Society: 4482-4491, 1972

In situ forming lyotropic liquid crystalline systems containing metronidazole-benzoate. Journal of Drug Delivery Science and Technology 15(5): 343-346, 2005

Lyotropic liquid crystalline phase behaviour in amphiphile-protic ionic liquid systems. Physical Chemistry Chemical Physics, PCCP 14(11): 3825-3836, 2012

Phytantriol Based "Stealth" Lyotropic Liquid Crystalline Nanoparticles for Improved Antitumor Efficacy and Reduced Toxicity of Docetaxel. Pharmaceutical Research 32(10): 3282-3292, 2015

In situ X-ray scattering studies of lyotropic liquid crystalline PBO and PBZT monofilament drawing. Journal of Polymer Science. Part B. Polymer Physics 32(16): 2567-2573, 1994

Etude sur le diagramme de phase de polymère cristal liquide lyotrope par chromatographie en phase gazeuse - Studies on phase diagram of lyotropic liquid crystalline polymer by gas chromatography. Kobunshi Ronbunshu (Tokyo) 43(4): 243-245, 1986