+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians



JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians



Immunological Reviews 286(1): 148-159



Immunity to pathogens is ensured through integration of early responses mediated by innate cells and late effector functions taking place after terminal differentiation of adaptive lymphocytes. In this context, innate lymphoid cells (ILCs) and adaptive T cells represent a clear example of how prototypical effector functions, including polarized expression of cytokines and/or cytotoxic activity, can occur with overlapping modalities but different timing. The ability of ILCs to provide early protection relies on their poised epigenetic state, which determines their propensity to quickly respond to cytokines and to activate specific patterns of signal-dependent transcription factors. Cytokines activating the Janus kinases (JAKs) and members of the signal transducer and activator of transcription (STAT) pathway are key regulators of lymphoid development and sustain the processes underlying T-cell activation and differentiation. The role of the JAK/STAT pathway has been recently extended to several aspects of ILC biology. Here, we discuss how JAK/STAT signals affect ILC development and effector functions in the context of immune responses, highlighting the molecular mechanisms involved in regulation of gene expression as well as the potential of targeting the JAK/STAT pathway in inflammatory pathologies.

(PDF emailed within 0-6 h: $19.90)

Accession: 065827495

Download citation: RISBibTeXText

PMID: 30294965

DOI: 10.1111/imr.12705


Related references

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nature Medicine 10(1): 48-54, 2004

Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 39(2): 386-399, 2013

Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases. Clinical Immunology (): -, 2016

The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells. Clinical and Experimental Allergy 45(1): 9-20, 2015

Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors. Methods in Molecular Biology 1799: 109-119, 2018

Notch signaling in group 3 innate lymphoid cells modulates their plasticity. Science Signaling 9(426): Ra45-Ra45, 2016

Androgen signaling negatively controls group 2 innate lymphoid cells. Journal of Experimental Medicine 214(6): 1581-1592, 2017

Regulation of group 2 innate lymphoid cells. Cytokine 87: 1-8, 2016

Neuroendocrine regulation of innate lymphoid cells. Immunological Reviews 286(1): 120-136, 2018

Innate lymphoid cells and fibrotic regulation. Immunology Letters, 2017

Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. Proceedings of the National Academy of Sciences of the United States of America 111(25): E2559-E2566, 2014

Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells. Frontiers in Immunology 8: 1069-1069, 2017

Multifaceted roles of interleukin-7 signaling for the development and function of innate lymphoid cells. Seminars in Immunology 24(3): 165-174, 2012

Development and regulation of RORγt(+) innate lymphoid cells. Febs Letters 588(22): 4176-4181, 2015

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells. Journal of Immunology 198(5): 1798-1803, 2017