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PD-L1 expression on tumor cells associated with favorable prognosis in surgically resected esophageal squamous cell carcinoma



PD-L1 expression on tumor cells associated with favorable prognosis in surgically resected esophageal squamous cell carcinoma



Human Pathology 2018



There is limited evidence regarding the relationship between programmed cell death ligand 1 (PD-L1) expression on tumor cells (TCs) and prognosis of esophageal squamous cell carcinoma (ESCC). This retrospective study aimed to investigate the clinical significance of PD-L1 expression in ESCC. To assess PD-L1 expression, we conducted immunohistochemistry studies using a tissue microarray encompassing 233 ESCC cases, stage I, II, and III, with detailed clinical data. PD-L1 expression on TCs was observed in 55.4% (129 of 233) of ESCC cases and was not associated with clinicopathological factors. ESCC patients with PD-L1-positive tumors showed significantly better overall survival (OS) and disease-free survival (DFS) than those with PD-L1-negative tumors (P=.023, P=.026, respectively). When patients were stratified into those with stage I-II (127, 54.5%) and stage III (106, 45.5%) disease and those without (134, 57.5%) and with (99, 42.5%) lymph node metastasis, the prognostic effect was inconsistent. The OS and DFS of patients with positive PD-L1 expression were significantly better in patients with stage I-II disease (P=.021, P=.015, respectively) and without lymph node metastasis (P=.009, P=.07, respectively) than their counterparts. Our results showed that PD-L1 expression on TCs was an independent predictor of prognosis of ESCC patients. However, the effect varied in patients with different stages and lymph node status. Positive PD-L1 expression was a favorable predictor in ESCC patients with stage I-II disease or without lymph node metastasis but not in patients with stage III disease or lymph node metastasis.

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Accession: 065874418

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PMID: 30296523

DOI: 10.1016/j.humpath.2018.09.014


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