+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pre, peri and posttransplant diabetes mellitus



Pre, peri and posttransplant diabetes mellitus



Current Opinion in Nephrology and Hypertension 28(1): 47-57



Label="PURPOSE OF REVIEW">The leading cause of death in both chronic kidney disease (CKD) and renal transplant patients is cardiovascular events. Post-transplant diabetes mellitus (PTx-DM), which is a major cardiovascular risk factor, is a metabolic disorder that affects 5.5-60.2% of renal allograft recipients by 1-year posttransplant (PTx). PTx-DM has been associated with a negative impact on patient and graft outcomes and survival.Label="RECENT FINDINGS">Individuals who develop PTx-DM are usually prone to this condition prior to and/or after developing CKD. Genetic factors, obesity, inflammation, medications and CKD all are risk factors for PTx-diabetes mellitus. The path to development of disease continues PTx frequently augmented by the use of diabetogenic maintenance immunosuppressive and some nonimmunosuppressive medications. These risk factors are usually associated with an increase in insulin resistance, a decrease in insulin gene expression and/or β-cell dysfunction and apoptosis.Label="SUMMARY">Some new anti-diabetes mellitus medications may help to improve the overall outcome; however, there is a real need for developing a preventive strategy. Identifying and targeting PTx-DM risk factors may help to guide the development of an effective programme. This could include the adoption of nondiabetogenic immunosuppressive protocols for high-risk patients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065886964

Download citation: RISBibTeXText

PMID: 30418189

DOI: 10.1097/mnh.0000000000000469


Related references

Hyperglycemia in the Posttransplant Period: NODAT vs Posttransplant Diabetes Mellitus. Journal of the Endocrine Society 2(11): 1314-1319, 2018

Microvascular Complications of Posttransplant Diabetes Mellitus in Kidney Transplant Recipients: A Longitudinal Study. Journal of Clinical Endocrinology and Metabolism 104(2): 557-567, 2019

Diabetes mellitus and anaesthesia. A survey of the peri-operative management of the patient with diabetes mellitus. Anaesthesia 43(7): 538-542, 1988

Posttransplant diabetes mellitus. Transplantation 75(10): 1769, 2003

HLA is not predictive of posttransplant diabetes mellitus. Transplantation Proceedings 38(3): 914-915, 2006

Posttransplant diabetes mellitus in Surabaya. Journal of the American Society of Nephrology 12(Program and Abstract Issue): 939A, 2001

Do immunosuppressants cause posttransplant diabetes mellitus?. Zhonghua Yi Xue Za Zhi 55(1): 37-41, 1995

Posttransplant diabetes mellitus--a review. Transplantation 58(12): 1289-1298, 1994

Rosiglitazone therapy of posttransplant diabetes mellitus. Transplantation 80(10): 1402-1405, 2005

Posttransplant diabetes mellitus after pancreas transplantation. American Journal of Transplantation 8(1): 175-182, 2008

Therapeutic management of posttransplant diabetes mellitus. Transplantation Reviews 22(2): 116-124, 2008

Impact and management of posttransplant diabetes mellitus. Transplantation 70(11 Suppl): Ss58-Ss63, 2000

Clinical impact of posttransplant diabetes mellitus. Transplantation Proceedings 33(5a Suppl): 19s-22s, 2001

Pretransplant screening for the development of posttransplant diabetes mellitus. Pediatric Research 43(4 Part 2): 84A, 1998

Posttransplant diabetes mellitus: incidence and risk factors. Transplantation Proceedings 41(7): 2811-2813, 2009