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Prevalence and associated risk factors on preterm birth, low birth weight, and small for gestational age among HIV-infected pregnant women in Hunan province, 2011-2017



Prevalence and associated risk factors on preterm birth, low birth weight, and small for gestational age among HIV-infected pregnant women in Hunan province, 2011-2017



Zhonghua Liu Xing Bing Xue Za Zhi 39(10): 1368-1374



目的: 了解湖南省孕产妇HIV感染者早产、低出生体重(LBW)和小于胎龄儿(SGA)的发生状况并探讨其影响因素。 方法: 以2011年1月至2017年12月湖南省预防艾滋病母婴传播管理信息系统报告的已分娩的孕产妇HIV感染者为研究对象,对其人口学特征、妊娠情况、抗病毒治疗(ART)、丈夫/性伴情况和妊娠结局等因素进行分析,分别计算早产、LBW和SGA发生率,采用多因素logistic回归分析其相关影响因素。 结果: 共纳入780例孕产妇HIV感染者,其早产率为7.9%(62/780),LBW发生率为9.9%(77/780),SGA发生率为21.3%(166/780)。孕产妇HIV感染者早产的危险因素包括妊娠期中重度贫血、妊娠期高血压疾病、<14孕周开始ART(与孕期未进行ART相比)和丈夫/性伴年龄>35岁(与26~30岁相比),其aOR值分别为4.59(95%CI:1.51~13.95)、4.90(95%CI:1.56~15.46)、2.40(95%CI:1.26~4.56)和2.29(95%CI:1.21~4.36)。妊娠期中重度贫血、妊娠合并HBV感染和<14孕周开始ART(与孕期未进行ART相比)是LBW的危险因素,其aOR值分别为3.28(95%CI:1.13~9.54)、4.37(95%CI:1.42~13.44)和2.68(95%CI:1.51~4.76)。妊娠合并HBV感染和<14孕周开始ART(与孕期未进行ART相比)是SGA的危险因素,其aOR值分别为4.41(95%CI:1.43~13.63)和2.67(95%CI:1.51~4.73)。 结论: 早产、LBW和SGA是湖南省孕产妇HIV感染者常见的不良妊娠结局,受妊娠合并症、ART和丈夫/性伴的年龄等因素影响。.

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