+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Protein malnutrition mitigates the effects of a high-fat diet on glucose homeostasis in mice

Protein malnutrition mitigates the effects of a high-fat diet on glucose homeostasis in mice

Journal of Cellular Physiology 234(5): 6313-6323

Nutrient malnutrition, during the early stages of development, may facilitate the onset of metabolic diseases later in life. However, the consequences of nutritional insults, such as a high-fat diet (HFD) after protein restriction, are still controversial. We assessed overall glucose homeostasis and molecular markers of mitochondrial function in the gastrocnemius muscle of protein-restricted mice fed an HFD until early adulthood. Male C57BL/6 mice were fed a control (14% protein-control diet) or a protein-restricted (6% protein-restricted diet) diet for 6 weeks. Afterward, mice received an HFD or not for 8 weeks (mice fed a control diet and HFD [CH] and mice fed a protein-restricted diet and HFD [RH]). RH mice showed lower weight gain and fat accumulation and did not show an increase in fasting plasma glucose and insulin levels compared with CH mice. RH mice showed higher energy expenditure, increased citrate synthase, peroxisome-proliferator-activated receptor gamma coactivator 1-alpha protein content, and higher levels of malate and α-ketoglutarate compared with CH mice. Moreover, RH mice showed increased AMPc-dependent kinase and acetyl coenzyme-A (CoA) carboxylase phosphorylation, lower intramuscular triacylglycerol content, and similar malonyl-CoA levels. In conclusion, protein undernourishment after weaning does not potentiate fat accumulation and insulin resistance in adult young mice fed an HFD. This outcome seems to be associated with increased skeletal muscle mitochondrial oxidative capacity and reduced lipids accumulation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 065892514

Download citation: RISBibTeXText

PMID: 30317568

DOI: 10.1002/jcp.27361

Related references

Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet. Metabolism: Clinical and Experimental 64(3): 368-379, 2015

Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice. Journal of Nutrition 135(8): 1854-1858, 2005

Medium term effects of a high protein diet on glucose homeostasis in rats. FASEB Journal 18(4-5): Abst 827 1, 2004

Dietary incorporation of whey protein isolate and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice. Journal of Intercultural Ethnopharmacology 6(3): 326-332, 2017

Effects of a high protein diet on plasma metabolite and hormone concentrations and glucose homeostasis in growing holstein steers. Journal of Dairy Science 72(Suppl. 1): 535-536, 1989

Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. Plos one 9(6): E100214, 2014

The effects of protein-energy malnutrition on blood glucose homeostasis. World Review of Nutrition and Dietetics 30: 107-147, 1978

GLP-2 as Beneficial Factor in the Glucose Homeostasis in Mice Fed a High Fat Diet. Journal of Cellular Physiology 230(12): 3029-3036, 2015

The effects of feeding a low protein or high protein diet on the glucose utilization in young mice brain. Acta Histochemica et Cytochemica 22(6): 742, 1989

Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. Plos one 13(8): E0201310, 2018

Effects of insulin infusion on glucose homeostasis and glucose metabolism in rainbow trout fed a high-carbohydrate diet. Journal of Experimental Biology 213(Pt 24): 4151-4157, 2010

Impaired lipid and glucose homeostasis in hexabromocyclododecane-exposed mice fed a high-fat diet. Environmental Health Perspectives 122(3): 277-283, 2014

Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environmental Health Perspectives 121(1): 105-110, 2013

Effects of diet composition on the development of glucose homeostasis in mice. Nutrition Reports International 37(2): 281-288, 1988

Whole body ARHGAP21 reduction improves glucose homeostasis in high-fat diet obese mice. Journal of Cellular Physiology 233(9): 7112-7119, 2018