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Recent advances in System biology based target identification and drug discovery



Recent advances in System biology based target identification and drug discovery



Current Topics in Medicinal Chemistry 2018



The enormous quantity of publicly available active chemical ligand and biological receptor data knowledge allows scientists to retreat several open question by the analysis and systematic integration of these complex unique data. Systems biology play crucial role through the constructive alignment of bio-physiochemical monitoring of gene, protein along with metabolites from the complex data. Further it integrated information within the data and responses (metabolic and signaling pathway) which lead to formulation of computational models for the elucidation of structure and function of molecular determinant. The system biology methods utilize the big complex high throughput data for the identification of whole drug target and for mechanism of action to lead compound characterization. Now these day the system biology is the one of most popular approached to characterize protein-ligand interaction on a large scale and vital to address a complex mode of drug action to clinical indications. The biological network of protein-ligand interaction also able to reveal the connection between molecular functions of cell to their physiological processes which helpful to designing safe and effective ligands which use for drug development. Here we review recent attempts to apply system biology based approaches with large-scale network analyses to predict novel interactions of ligand and targets. We also deliver an essential step involve in the discovery and development of such multi-target drugs by identifying the group of proteins targeted by a particular ligand, leading to innovation in therapeutic research.

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Accession: 065898844

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PMID: 30360719


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