+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Reduction in gray matter of cerebellum in schizophrenia and its influence on static and dynamic connectivity



Reduction in gray matter of cerebellum in schizophrenia and its influence on static and dynamic connectivity



Human Brain Mapping 40(2): 517-528



Pathophysiological and atrophic changes in the cerebellum have been well-documented in schizophrenia. Reduction of gray matter (GM) in the cerebellum was confirmed across cognitive and motor cerebellar modules in schizophrenia. Such abnormalities in the cerebellum could potentially have widespread effects on both sensorimotor and cognitive symptoms. In this study, we investigated how reduction change in the cerebellum affects the static and the dynamic functional connectivity (FC) between the cerebellum and cortical/subcortical networks in schizophrenia. Reduction of GM in the cerebellum was confirmed across the cognitive and motor cerebellar modules in schizophrenic subjects. Results from this study demonstrates that the extent of reduction of GM within cerebellum correlated with increased static FCs between the cerebellum and the cortical/subcortical networks, including frontoparietal network (FPN), and thalamus in patients with schizophrenia. Decreased GM in the cerebellum was also associated with a declined dynamic FC between the cerebellum and the FPN in schizophrenic subjects. The severity of patients' positive symptom was related to these structural-functional coupling score of cerebellum. These findings identified potential cerebellar driven functional changes associated with positive symptom deficits. A post hoc analysis exploring the effect of changed FC within cerebellum, confirmed that a significant positive relationship, between dynamic FCs of cerebellum-thalamus and intracerebellum existed in patients, but not in controls. The reduction of GM within the cerebellum might be associated with modulation of cerebellum-thalamus, and contributes to the dysfunctional cerebellar-cortical communication in schizophrenia. Our results provide a new insight into the role of cerebellum in understanding the pathophysiological of schizophrenia.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065900574

Download citation: RISBibTeXText

PMID: 30240503

DOI: 10.1002/hbm.24391


Related references

Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia. Schizophrenia Research 108(1-3): 57-68, 2009

Multimodal Classification of Schizophrenia Patients with MEG and fMRI Data Using Static and Dynamic Connectivity Measures. Frontiers in Neuroscience 10: 466, 2016

Classification of schizophrenia and bipolar patients using static and dynamic resting-state fMRI brain connectivity. Neuroimage 134: 645-657, 2016

Gray Matter Volume and Resting-State Functional Connectivity of the Motor Cortex-Cerebellum Network Reflect the Individual Variation in Masticatory Performance in Healthy Elderly People. Frontiers in Aging Neuroscience 7: 247, 2015

Prefrontal gray matter volume reduction in first episode schizophrenia. Cerebral Cortex 11(4): 374-381, 2001

Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?. Schizophrenia Research 118(1-3): 62-68, 2010

Shared Genetic Risk of Schizophrenia and Gray Matter Reduction in 6p22.1. Schizophrenia Bulletin 45(1): 222-232, 2019

Fusiform gyrus gray matter reduction and visual processing in schizophrenia. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 314 18, 2003

Extensive gray matter volume reduction in treatment-resistant schizophrenia. International Journal of Neuropsychopharmacology 18(7): Pyv016, 2015

Regional gray matter reduction correlates with subjective quality of life in schizophrenia. Journal of Psychiatric Research 47(4): 548-554, 2013

Lack of progressive gray matter reduction of the superior temporal subregions in chronic schizophrenia. Schizophrenia Research 117(1): 101-102, 2010

Social impairment in schizophrenia revealed by Autism-Spectrum Quotient correlated with gray matter reduction. Social Neuroscience 6(5-6): 548-558, 2011

Progressive Reduction in Gray Matter in Patients with Schizophrenia Assessed with MR Imaging by Using Causal Network Analysis. Radiology 287(2): 633-642, 2018

Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia. Schizophrenia Research 123(2-3): 153-159, 2010

Ventral striatum gray matter density reduction in patients with schizophrenia and psychotic emotional dysregulation. Neuroimage. Clinical 4: 232-239, 2014