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Synovial sarcoma diagnosis on fine needle cytology sample confirmed by fluorescence in situ hybridisation



Synovial sarcoma diagnosis on fine needle cytology sample confirmed by fluorescence in situ hybridisation



Cytopathology 30(3): 314-317



Synovial sarcoma (SS) is a mesenchymal neoplasm usually affecting adolescents and young adults, with one third of cases occuring in the first two decades of life. SS is characterized by the specific balanced chromosomal translocation t(X;18)(p11;q11), resulting in the fusion of SYT gene on chromosome 18 with SSX1, SSX2 or SSX4 gene on chromosome X. SS predominantly arises in the soft tissue around large joints of the lower extremities. Other sites include head and neck, thorax, heart or pericardium, abdomen and pelvis. This article is protected by copyright. All rights reserved.

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Accession: 065930624

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PMID: 30417957

DOI: 10.1111/cyt.12651


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