+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The role of oxidative stress in the biology of melanoma: A systematic review

The role of oxidative stress in the biology of melanoma: A systematic review

Pathology, Research and Practice 2018

Melanoma is the most aggressive skin tumour, which incidence is rising fast over the year. The metastatic stage of disease is extremely difficult to treat and the mortality rate is still high. Emerging evidence suggested that oxidative stress (OS) is involved in the pathophysiological pathways of several chronic diseases and in the transformation and progression of many common cancers, including melanoma. In particular, it has emerged that OS interacts with inflammatory and immune response, all taking part in the melanomagenic process. In light of the interest shown by the scientific community for this topic, it was analysed the association between melanoma and oxidative stress. A systematic review was performed according to PRISMA guideline employing PubMed database. It identified n = 29 articles which investigated this aspect. Melanoma cells resulted to have adaptive mechanisms to overcome effects of high reactive oxygen species (ROS) levels. Furthermore, OS influences the metastatic ability of melanoma cells and their resistance to therapy. Nonetheless, the included studies were conducted on heterogeneous patient population and with differences in the design of the studies and in the protocols. Therefore, it is mandatory performing further studies which analyze all the aspect of OS pathways: ROS imbalance, its effect to proliferation and metastasis, role of microenvironment, ROS effect to drug resistance. All this in order to understand the role of oxidative stress in the complex biology of melanoma and to provide possibilities of defining new strategy of therapy.

(PDF emailed within 0-6 h: $19.90)

Accession: 065950120

Download citation: RISBibTeXText

PMID: 30501931

DOI: 10.1016/j.prp.2018.11.020

Related references

Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review. Calcified Tissue International 101(6): 553-563, 2017

The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstetrical and Gynecological Survey 62(5): 335-47; Quiz 353-4, 2007

The Role of Biomarkers of Oxidative Stress in Breast Cancer Risk and Prognosis: A Systematic Review of the Epidemiologic Literature. Journal of Women's Health 26(5): 467-482, 2017

Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis. Plos One 11(12): E0166915, 2017

The beneficial role of Naringin- a citrus bioflavonoid, against oxidative stress-induced neurobehavioral disorders and cognitive dysfunction in rodents: A systematic review and meta-analysis. Biomedicine and PharmacoTherapy 94: 909-929, 2017

Systematic review of oxidative stress associated with pneumoperitoneum. British Journal of Surgery 96(8): 836-850, 2009

Lead Exposure and Oxidative Stress: A Systematic Review. Reviews of Environmental Contamination and Toxicology 236: 193-238, 2015

Oxidative Stress and Endometriosis: A Systematic Review of the Literature. Oxidative Medicine and Cellular Longevity 2017: 7265238, 2018

A systematic review of p53 regulation of oxidative stress in skeletal muscle. Redox Report 23(1): 100-117, 2018

Blood reflects tissue oxidative stress: a systematic review. Biomarkers 20(2): 97-108, 2016

Oxidative stress in benign prostatic hyperplasia: a systematic review. Urologia Internationalis 94(3): 249-254, 2016

Antipsychotic medication and oxidative cell stress: a systematic review. Journal of Clinical Psychiatry 72(3): 273-285, 2011

Oxidative stress and frailty: A systematic review and synthesis of the best evidence. Maturitas 99: 66-72, 2017

Nutrition and oxidative stress: a systematic review of human studies. International Journal of Food Sciences and Nutrition 64(3): 312-326, 2013

Oxidative stress biomarkers in patients with endometriosis: systematic review. Archives of Gynecology and Obstetrics 286(4): 1033-1040, 2013