+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Oxidative Medicine and Cellular Longevity 2018: 5076271-5076271

Modern technologies relying on wireless communication systems have brought increasing levels of electromagnetic field (EMF) exposure. This increased research interest in the effects of these radiations on human health. There is compelling evidence that EMFs affect cell physiology by altering redox-related processes. Considering the importance of redox milieu in the biological competence of oocyte and sperm, we reviewed the existing literature regarding the effects of EMFs on reproductive systems. Given the role of mitochondria as the main source of reactive oxygen species (ROS), we focused on the hypothesis of a mitochondrial basis of EMF-induced reproductive toxicity. MEDLINE, Web of Science, and Scopus database were examined for peer-reviewed original articles by searching for the following keywords: "extremely low frequency electromagnetic fields (ELF-EMFs)," "radiofrequency (RF)," "microwaves," "Wi-Fi," "mobile phone," "oxidative stress," "mitochondria," "fertility," "sperm," "testis," "oocyte," "ovarian follicle," and "embryo." These keywords were combined with other search phrases relevant to the topic. Although we reported contradictory data due to lack of uniformity in the experimental designs, a growing body of evidence suggests that EMF exposure during spermatogenesis induces increased ROS production associated with decreased ROS scavenging activity. Numerous studies revealed the detrimental effects of EMFs from mobile phones, laptops, and other electric devices on sperm quality and provide evidence for extensive electron leakage from the mitochondrial electron transport chain as the main cause of EMF damage. In female reproductive systems, the contribution of oxidative stress to EMF-induced damages and the evidence of mitochondrial origin of ROS overproduction are reported, as well. In conclusion, mitochondria seem to play an important role as source of ROS in both male and female reproductive systems under EMF exposure. Future and more standardized studies are required for a better understanding of molecular mechanisms underlying EMF potential challenge to our reproductive system in order to improve preventive strategies.

(PDF emailed within 0-6 h: $19.90)

Accession: 065992284

Download citation: RISBibTeXText

PMID: 30533171

DOI: 10.1155/2018/5076271

Related references

The Effects of Mobile Phone Radiofrequency Electromagnetic Fields on β-Amyloid-Induced Oxidative Stress in Human and Rat Primary Astrocytes. Neuroscience 2019, 2019

Role of mitochondria in ultraviolet-induced oxidative stress. Journal of Cellular Biochemistry 80(2): 216-222, 2000

The role of mitochondria in ultraviolet-induced oxidative stress. British Journal of Dermatology 148(4): 865, 2003

Oxidative stress-induced autophagy in plants: the role of mitochondria. Plant Physiology and Biochemistry 59: 11-19, 2013

Electromagnetic fields, oxidative stress, and neurodegeneration. International Journal of Cell Biology 2012: 683897, 2012

Zinc induced apoptosis in HEP-2 cancer cells: the role of oxidative stress and mitochondria. BioFactors 23(2): 107-120, 2005

Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2+ signaling molecular pathways in breast cancer. Journal of Receptor and Signal Transduction Research 32(6): 290-297, 2013

The role of mitochondria in the development of radiation-induced oxidative stress in K562 leukemia cells. Bulletin of Experimental Biology and Medicine 154(5): 631-634, 2014

Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiology of Disease 18(3): 618-627, 2005

Role of mitochondria in exercise-induced oxidative stress in skeletal muscle from hyperthyroid rats. Archives of Biochemistry and Biophysics 463(1): 12-18, 2007

Oxidative stress and brain mitochondria swelling induced by endosulfan and protective role of quercetin in rat. Environmental Science and Pollution Research International 22(10): 7776-7781, 2015

In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders. Free Radical Biology and Medicine 41(11): 1694-1703, 2006

Acrolein-induced cell death in PC12 cells: role of mitochondria-mediated oxidative stress. Neurochemistry International 47(7): 449-457, 2005

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotoxicity Research 5(7): 491-504, 2004

An in vitro study of the ameliorative role of α-tocopherol on methotrexate-induced oxidative stress in rat heart mitochondria. Journal of Basic and Clinical Physiology and Pharmacology 23(4): 163-168, 2013