+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Polymorphism of mitochondrial tRNA genes associated with the number of pigs born alive



Polymorphism of mitochondrial tRNA genes associated with the number of pigs born alive



Journal of Animal Science and Biotechnology 9: 86



Mutations in mitochondrial tRNA genes have been widely reported association with human reproductions. It is also important to explore the effect on the number of piglets born alive (NBA). Here, 1017 sows were used to investigate the association between polymorphisms in mitochondrial tRNA genes and NBA. In total, 16 mutations were found in mitochondrial tRNA genes, of which 13 mutations were significantly associated with NBA (P < 0.05). The reproductions of mutant carriers were significantly greater than that of wild carriers by 0.989 piglets born alive/sow farrowing. To test whether the mutations altered the structure of mitochondrial tRNAs, the secondary and tertiary structures were predicted. In result, C2255T changed the secondary structure of tRNA-Val by elongating the T stem and shrinking the T loop, and C2255T and G2259A in the tRNA-Val gene, C6217T and T6219C in the tRNA-Ala gene, and T15283C in the tRNA-Glu gene altered the tertiary structure of their tRNAs, respectively by changing the folding form of the T arm, and C16487T in the tRNA-Thr gene changed the tertiary structure of mitochondrial tRNA-Thr by influencing the folding form of the acceptor arm. Results highlight the effect of mitochondrial tRNA genes on the number of piglets born alive, and suggest that polymorphic sites of the tRNA genes be genetic markers for selection of pig reproduction.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 065993403

Download citation: RISBibTeXText

PMID: 30534375

DOI: 10.1186/s40104-018-0299-0


Related references

Genetic improvement of litter size in pigs selected for total number born or number born alive. Japanese Journal of Swine Science 43(1): 16-19, 2006

Genome-wide association study of total number born and number born alive in pigs using both compressed mixed linear model and Bayes model. Yi Chuan 34(10): 1261-1270, 2012

Effects of inbreeding on number of piglets born total, born alive and weaned in Austrian Large White and Landrace pigs. Archiv Fur Tierzucht-Archives of Animal Breeding 52(1): 51-64, 2009

A genome-wide single nucleotide polymorphism and copy number variation analysis for number of piglets born alive. Bmc Genomics 20(1): 321, 2019

Estimated breeding values for number born alive in pigs - do they really work?. Manipulating pig production X Proceedings of the Tenth Biennial Conference of the Australasian Pig Science Association APSA, held in Christchurch, New Zealand, 27th to 30th November, 2005: 102, 2005

Development of an animal model for national swine evaluation of number of pigs born alive. Journal of Animal Science 70(Suppl. 1): 147, 1992

Analysis of systematic influences on number of pigs born alive by using Bayes-based estimation procedures. Zuchtungskunde 74(3): 183-193, 2002

Genome-wide association studies for the number of animals born alive and dead in duroc pigs. Theriogenology 139: 36-42, 2019

Restricted maximum likelihood estimation of variance components from field data for number of pigs born alive. Journal of Animal Science 71(11): 2905-2909, 1993

Derivative free REML estimation of genetic and environmental parameters for number of pigs born alive and 21 d litter weights. Journal of Animal Science 71(Suppl. 1): 92, 1993

Number of pigs born alive in parity 1 sows associated with lifetime performance and removal hazard in high- or low-performing herds in Japan. Preventive Veterinary Medicine 121(1-2): 108-114, 2015

Genomic DNA sequences of mitochondrial tRNA genes in fungi Penicillium chrysogenum KCTC1262: tRNA(arg), tRNA(asn) and tRNA(tyr) genes. Nucleic Acids Research 20(21): 5842, 1992

Restricted maximum likelihood estimation of genetic parameters for number of pigs born alive estimated from field data using sparse matrix inversion. Journal of Animal Science 70(Suppl. 1): 147, 1992

Number of genes and base composition of mitochondrial tRNA from Saccharomyces cerevisiae. Nucleic Acids Research 2(6): 831-838, 1975

Number of genes and base composition of mitochondrial tRna from Saccharomyces cerevistae. Nucleic Acids Research 2(6): 831-838, 1975