+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Diagnostic Accuracy of Digital Retinal Fundus Image Analysis in Detecting Diabetic Maculopathy in Type 2 Diabetes Mellitus

Diagnostic Accuracy of Digital Retinal Fundus Image Analysis in Detecting Diabetic Maculopathy in Type 2 Diabetes Mellitus

Ophthalmic Research 2018: 1-7

Digital retinal imaging is the gold standard technique for diabetic retinopathy (DR) and diabetic macular oedema (DME) assessment during DR screening. To evaluate the diagnostic accuracy of digital retinal fundus image (DRFI) analysis in detecting DME using three manual grading systems (MGS) and comparing it with optical coherence tomography (OCT) findings. A total of 287 DRFI of 287 eyes were analysed. Non-stereoscopic 45° images were acquired using a Kowa VX-20 camera and were graded according to three MGS: Early Treatment Diabetic Retinopathy Study (ETDRS), International Clinical Diabetic Retinopathy (ICDR), and United Kingdom National Screening Committee (UKNSC). The two graders were masked to the patient's clinical DR status. DME characteristics were analysed using OCTs. A very good agreement in detecting DME was found with Cohen's κ = 0.83 (ICDR vs. ETDRS), κ = 0.83 (ICDR vs. UKNSC), and κ = 0.82 (ETDRS vs. UKNSC). Sensitivity and specificity of DRFI analysis in DME assessment were 70.0 and 69.6% for UKNSC, 71.9 and 67.4% for ETDRS, and 70.9 and 65.2% for ICDR, respectively. Positive and negative predictive values were 91.7 and 32.7% for UKNSC, 91.4 and 33.3% for ETDRS, and 90.7 and 31.9% for ICDR, respectively. On OCT scans, micro-architectural damages of both inner and outer retinal layers and mean ganglion cell layer thickness showed a significant association with the presence of DME detected with DRFI analysis. Despite the low negative predictive value, the good specificity and sensitivity of DRFI in detecting DME make it a useful tool in a routine clinical setting, and its potential in diabetic eye screening is yet to be realized.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 066010878

Download citation: RISBibTeXText

PMID: 30554213

DOI: 10.1159/000494499

Related references

Analysis of retinal neovascularization with a computer-assisted digital fundus image diagnostic system. IOVS 39(4): S595, March 15, 1998

Accuracy of single-field nonmydriatic digital fundus image in screening for diabetic retinopathy. Journal of the Medical Association of Thailand 91(9): 1397-1403, 2008

Systematic review and meta-analysis of diagnostic accuracy of detection of any level of diabetic retinopathy using digital retinal imaging. Systematic Reviews 7(1): 182, 2018

Prevalence and risk factors for diabetic maculopathy, and its relationship to diabetic retinopathy in elderly Japanese patients with type 2 diabetes mellitus. Geriatrics and Gerontology International 12 Suppl 1: 134-140, 2012

Long-term risk factors for diabetic retinopathy and diabetic maculopathy in elderly Japanese patients with type 2 diabetes mellitus. Geriatrics and Gerontology International 12 Suppl 1: 141-144, 2012

Quantification of diabetic maculopathy by digital imaging of the fundus. Eye 5: 130-137, 1991

Diagnostic accuracy of HbA1c in detecting gestational diabetes mellitus. Journal of Maternal-Fetal & Neonatal Medicine 2019: 1-11, 2019

Diagnostic accuracy of disorganization of the retinal inner layers in detecting macular capillary non-perfusion in diabetic retinopathy. Clinical and Experimental Ophthalmology 43(8): 735-741, 2016

Diabetic retinopathy screening using digital non-mydriatic fundus photography and automated image analysis. Acta Ophthalmologica Scandinavica 82(6): 666-672, 2004

Automated Diabetic Retinopathy Screening and Monitoring Using Retinal Fundus Image Analysis. Journal of Diabetes Science and Technology 10(2): 254-261, 2016

Is fundus photography useful in screening for diabetic retinopathy in patients with type II diabetes mellitus?. Nederlands Tijdschrift Voor Geneeskunde 137(34): 1713-1717, 1993

The effect of the vitreal adherence in the macular region in diabetic maculopathy course based on FA picture in patients with type 2 of diabetes mellitus. Klinika Oczna 109(4-6): 160-164, 2007

Meta-Analysis of Diagnostic Accuracy of Retinopathy for the Detection of Diabetic Kidney Disease in Adults With Type 2 Diabetes. Canadian Journal of Diabetes 2019, 2019

Systematic review of the diagnostic accuracy of the single, two and three field digital retinal photography for screening diabetic retinopathy. Jbi Library of Systematic Reviews 9(16): 491-537, 2011

Macrovascular topography in diabetic retinopathy analysis of fundus pictures using high resolution digital image processing. Investigative Ophthalmology & Visual Sciencestr. Issue: 262, 1988