Section 67
Chapter 66,034

Morphokinetic parameters in chromosomal translocation carriers undergoing preimplantation genetic testing

Lammers, J.; Reignier, A.; Splingart, C.; Moradkhani, K.; Barrière, P.; Fréour, T.

Reproductive Biomedicine Online 38(2): 177-183


ISSN/ISBN: 1472-6491
PMID: 30579822
DOI: 10.1016/j.rbmo.2018.11.006
Accession: 066033265

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Can embryo morphokinetic parameters help identify unbalanced embryos in translocation carriers? This retrospective study was conducted in 67 translocation carriers undergoing 105 preimplantation genetic testing cycles for chromosomal structural rearrangements (PGT-SR) without aneuploidy screening (PGT-A). Using time-lapse imaging analysis, morphokinetic parameters of balanced and unbalanced embryos were compared, as well as the frequency of abnormal cellular events. The performance of a previously published prediction model of aneuploidy was also tested in this population. Significant differences were observed between balanced and unbalanced embryos for some morphokinetic parameters: t5 (P = 0.0067), t9+ (P = 0.0077), cc2 (P = 0.0144), s2 (P = 0.0003) and t5-t2 (P = 0.0028). Also, multinucleation at the two- or four-cell stages, abnormal division and cell exclusion at the morula stage were significantly (all P < 0.05) more frequent in unbalanced than in balanced embryos. None, however, could accurately predict embryo chromosomal status. A previously published morphokinetic prediction model for embryo aneuploidy did not adequately classify balanced and unbalanced embryos. No significant morphokinetic predictor of chromosomal status could be found. Time-lapse should not be used as a diagnostic tool for chromosomal status in translocation carriers.

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