+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Screening for Gastric and Small Intestinal Mucosal Injury with Magnetically Controlled Capsule Endoscopy in Asymptomatic Patients Taking Enteric-Coated Aspirin



Screening for Gastric and Small Intestinal Mucosal Injury with Magnetically Controlled Capsule Endoscopy in Asymptomatic Patients Taking Enteric-Coated Aspirin



Gastroenterology Research and Practice 2018: 2524698-2524698



To investigate gastric and small intestinal mucosal injury in asymptomatic patients taking enteric-coated aspirin using magnetically controlled capsule endoscopy. Patients taking enteric-coated aspirin (aspirin group) and healthy controls (control group) were recruited from Beijing Anzhen Hospital, Capital Medical University, between September 2017 and May 2018, and undertook magnetically controlled capsule endoscopy. Twenty-six subjects were recruited to the aspirin group and twenty-six to the control group; the median Gastrointestinal Symptom Rating Scale scores were 3.50 and 3.00 (P = 0.200), the median gastric Lanza scores were 2.50 and 1.00 (P < 0.001), the small intestinal Lanza scores were 1.00 and 0.00 (P < 0.001), the gastric controlled examination times were 50.0 and 51.0 min (P = 0.171), the small intestinal transit times were 240.0 and 238.0 min (P = 0.654), and the capsule excretion times were 24.0 and 24.0 hours (P = 0.956), respectively. Rates of gastric and small intestinal mucosal injuries were significantly higher in patients without obvious gastrointestinal symptoms taking enteric-coated aspirin compared to healthy controls. Magnetically controlled capsule endoscopy constitutes a safe, real-time screening modality for gastric and small intestinal mucosal injury in patients taking enteric-coated aspirin.

(PDF emailed within 0-6 h: $19.90)

Accession: 066034783

Download citation: RISBibTeXText

PMID: 30581462

DOI: 10.1155/2018/2524698


Related references

Comparison of small-bowel mucosal injury between low-dose aspirin and non-aspirin non-steroidal anti-inflammatory drugs: a capsule endoscopy study. Digestion 89(3): 225-231, 2015

Screening for gastric cancer with magnetically controlled capsule gastroscopy in asymptomatic individuals. Gastrointestinal Endoscopy 88(3): 466-474.E1, 2018

Does magnetically assisted capsule endoscopy improve small bowel capsule endoscopy completion rate? A randomised controlled trial. Endoscopy International Open 4(2): E215-E221, 2016

Differences in the severity of small bowel mucosal injury based on the type of aspirin as evaluated by capsule endoscopy. Digestive and Liver Disease 44(10): 833-838, 2013

PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: results of two 6-month, phase 3 studies. American Heart Journal 168(4): 495-502.E4, 2015

Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study. Bmc Gastroenterology 13: 108, 2013

Omeprazole increased small intestinal mucosal injury in two of six disease-free cases evaluated by capsule endoscopy. Digestive Endoscopy 26(5): 676-679, 2015

Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage. Scandinavian Journal of Gastroenterology 45(3): 292-298, 2010

A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel. Digestive Diseases and Sciences 59(8): 1885-1890, 2014

Gastric preparation for magnetically controlled capsule endoscopy: A prospective, randomized single-blinded controlled trial. Digestive and Liver Disease 50(1): 42-47, 2017

Does rebamipide prevent gastric mucosal injury in patients taking aspirin and clopidogrel?. Digestive Diseases and Sciences 59(8): 1671-1673, 2014

Prevention and treatment of gastric mucosal injury in patients taking low-dose aspirin. Nihon Rinsho. Japanese Journal of Clinical Medicine 69 Suppl 7: 450-454, 2012

Accuracy of Magnetically Controlled Capsule Endoscopy, Compared With Conventional Gastroscopy, in Detection of Gastric Diseases. Clinical Gastroenterology and Hepatology 14(9): 1266-1273.E1, 2017

Gastroduodenal mucosal injury in patients taking low-dose aspirin and the role of gastric mucoprotective drugs: possible effect of rebamipide. Journal of Clinical Biochemistry and Nutrition 47(1): 27-31, 2010

Su1163 Usefulness of Small Intestinal Reexamination for Patients With Obscure Gastrointestinal Bleeding With Negative Capsule Endoscopy Findings: Comparison of Balloon-Assisted Enteroscopy and Capsule Endoscopy. Gastrointestinal Endoscopy 85(5): Ab297-Ab298, 2017