+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study



Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study



Clinical Therapeutics 41(1): 130-136



To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). The observed MNA necessitates adherence-enhancing interventions encompassing the entire post-heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066043608

Download citation: RISBibTeXText

PMID: 30591285

DOI: 10.1016/j.clinthera.2018.11.007


Related references

The international prevalence and variability of nonadherence to the nonpharmacologic treatment regimen after heart transplantation: Findings from the cross-sectional BRIGHT study. Clinical Transplantation 32(7): E13280, 2018

Prevalence and correlates of medication non-adherence among kidney transplant recipients more than 6 months post-transplant: a cross-sectional study. Bmc Nephrology 14: 261, 2013

Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: The international BRIGHT study. American Journal of Transplantation 18(6): 1447-1460, 2018

Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication nonadherence as risk factor for post-transplant nonadherence to immunosuppressives: the Swiss Transplant Cohort Study. Transplant International 27(7): 657-666, 2014

Medication errors: an important component of nonadherence to medication in an outpatient population of lung transplant recipients. American Journal of Transplantation 7(11): 2561-2566, 2007

Engagement with Medication Among Kidney Transplant Recipients - A Descriptive Cross-Sectional Study. Nephrology Nursing Journal 46(1): 49-57, 2019

Practice patterns to improve pre and post-transplant medication adherence in heart transplant centres: a secondary data analysis of the international BRIGHT study. European Journal of Cardiovascular Nursing 2017: 1474515117747577, 2017

The prevalence of medication nonadherence in post-myocardial infarction survivors and its perceived barriers and psychological correlates: a cross-sectional study in a cardiac health facility in Malaysia. Patient Preference and Adherence 11: 1975-1985, 2017

Self-reported non-adherence to immunosuppressive medication in adult lung transplant recipients-A single-center cross-sectional study. Clinical Transplantation 32(4): E13214, 2018

Non-adherence to immunosuppressive medication in renal transplant recipients within the scope of the Integrative Model of Behavioral Prediction: a cross-sectional study. Clinical Transplantation 24(2): 213-222, 2010

Prevalence and correlates of self-reported pretransplant nonadherence with medication in heart, liver, and lung transplant candidates. Transplantation 79(11): 1588-1595, 2005

Incidence and factors associated with medication nonadherence in patients with mental illness: a cross-sectional study. Journal of Postgraduate Medicine 61(4): 251-256, 2015

Predictors of medication nonadherence in patients with systemic lupus erythematosus in Sichuan: a cross-sectional study. Patient Preference and Adherence 12: 1505-1511, 2018

Factors associated with nonadherence to medication in kidney transplant recipients. Nephron. Clinical Practice 117(1): C33, 2011

Modifiable risk factors for non-adherence to immunosuppressants in renal transplant recipients: a cross-sectional study. Nephrology Dialysis Transplantation 19(12): 3144-3149, 2004