+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Utility of serum and bronchoalveolar lavage fluid galactomannan in the diagnosis of chronic pulmonary aspergillosis



Utility of serum and bronchoalveolar lavage fluid galactomannan in the diagnosis of chronic pulmonary aspergillosis



Journal of Clinical Microbiology 2019



Background and aim: The value of serum and bronchoalveolar lavage fluid (BALF) galactomannan (GM) in diagnosing chronic pulmonary aspergillosis (CPA) remains unclear. Herein, we study the diagnostic efficacy of GM in the diagnosis of CPA.Methods: We included consecutive treatment-naïve subjects with CPA. For calculating the specificity of serum GM, we enrolled diseased controls (minimally symptomatic subjects previously treated for pulmonary tuberculosis, not meeting the criteria for CPA). To calculate the specificity of BALF-GM, subjects with pulmonary disorders other than CPA who underwent bronchoscopy were included. We determined the cut-off of serum and BALF-GM using receiver operating characteristic (ROC) curve analysis.Results: We enrolled 243 consecutive treatment-naïve subjects (53.5% males) of CPA with a mean (SD) age of 43.6 (14.7) years. Forty-five (60% males; age, 46.7 [15.7] years) and 27 subjects (59.3% males; age, 52.6 [12.8] years) served as controls for serum and BALF-GM, respectively. The best cut-off value for serum and BALF-GM was 0.55 (AUROC, 0.605; sensitivity, 38%; specificity, 87%) and 1.375 (AUROC, 0.836; sensitivity 68%; specificity, 93%), respectively. At a cut-off value of 2.5, BALF-GM had a sensitivity and specificity of 50% and 100%, respectively.Conclusions: BALF-GM performs better than serum GM and may be helpful in the diagnosis of CPA in selected patients. More studies are required to confirm our findings.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066075152

Download citation: RISBibTeXText

PMID: 30626661

DOI: 10.1128/JCM.01821-18


Related references

Clinical utility of Aspergillus galactomannan and PCR in bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in patients with haematological malignancies. Diagnostic Microbiology and Infectious Disease 79(3): 322-327, 2015

The diagnosis of invasive and noninvasive pulmonary aspergillosis by serum and bronchoalveolar lavage fluid galactomannan assay. Biomed Research International 2015: 943691, 2015

Bronchoalveolar lavage fluid galactomannan detection for diagnosis of invasive pulmonary aspergillosis in chronic obstructive pulmonary disease. Medical Mycology 51(7): 688-695, 2014

A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: comparison with the diagnostic performance of galactomannan and of (1→ 3)-β-d-glucan chromogenic assay in serum samples. Clinical Microbiology and Infection 17(7): 1053-1060, 2011

Role of galactomannan determinations in bronchoalveolar lavage fluid samples from critically ill patients with chronic obstructive pulmonary disease for the diagnosis of invasive pulmonary aspergillosis: a prospective study. Critical Care 16(4): R138, 2016

Quantitative Real-Time PCR and Platelia Galactomannan Assay for the Diagnosis of Invasive Pulmonary Aspergillosis: Bronchoalveolar Lavage Fluid Performs Better Than Serum in Non-neutropaenic Patients. Mycopathologia 181(9-10): 625-629, 2017

Bronchoalveolar lavage fluid galactomannan for diagnosis of invasive pulmonary aspergillosis. Clinical Infectious Diseases 50(7): 1070; Author Reply 1071-2, 2010

Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis. Medical Mycology 50(8): 811-817, 2013

Diagnostic value of the combinations of bronchoalveolar lavage fluid galactomannan test and serum galactomannan test in invasive pulmonary aspergillosis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 31(3): 331-335, 2019

Evaluation of Galactomannan Testing, the Aspergillus -Specific Lateral-Flow Device Test and Levels of Cytokines in Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis. Frontiers in Microbiology 9: 2223, 2018

Usefulness of Two Aspergillus PCR Assays and Aspergillus Galactomannan and β-d-Glucan Testing of Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis. Journal of Clinical Microbiology 55(6): 1738-1746, 2017

Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients. Canadian Respiratory Journal 2017: 3685261, 2018

Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis. Journal of Infection 61(6): 492-498, 2011

Application of detecting bronchoalveolar lavage fluid Aspergillus galactomannan antigen in the diagnosis of pulmonary aspergillosis. Zhonghua Yi Xue Za Zhi 92(32): 2268-2270, 2013

Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients. Bmc Infectious Diseases 10: 44, 2010