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Severe Diarrhea in the Setting of Immune Checkpoint Inhibitors

Severe Diarrhea in the Setting of Immune Checkpoint Inhibitors

Case Reports in Gastroenterology 12(3): 704-708

Immune checkpoint inhibitors (ICPIs) are novel therapeutic agents targeting a variety of cancers by enhanced T cell activation. Immune-related adverse events (irAEs) commonly occur with ICPI use and can affect multiple organ systems including the gastrointestinal tract. Due to irAEs, the use of ICPIs is limited in autoimmune diseases. We present a case of microscopic colitis diagnosed after the initiation of nivolumab and a case of ipilimumab colitis and Clostridium difficile in the setting of Crohn's colitis.

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Accession: 066079004

Download citation: RISBibTeXText

PMID: 30631256

DOI: 10.1159/000493183

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