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Hyperthermic intraperitoneal chemotherapy (HIPEC). Mechanisms of action and the role of HIPEC in the treatment of peritoneal carcinomatosis



Hyperthermic intraperitoneal chemotherapy (HIPEC). Mechanisms of action and the role of HIPEC in the treatment of peritoneal carcinomatosis



Annali Italiani di Chirurgia 89: 513-527



La carcinosi peritoneale rappresenta lo stadio avanzato e finale dell’impegno neoplastico del peritoneo, sebbene spesso non sia accompagnata da diffusione sistemica delle neoplasie. Lo sviluppo dell’industria farmaceutica in combinazione con tecniche chirurgiche avanzate ha contribuito a migliorare l’esito di questi pazienti, considerati a lungo senza risorse risolutive. La citoriduzione tumorale seguita da chemioterapia intraperitoneale ipertermica (HIPEC) è naturalmente il trattamento di scelta per questi pazienti, eseguito con impegno multimodale, scelto con cura, seguendo un consenso multidisciplinare. In questo articolo abbiamo esaminato i principali aspetti della procedura HIPEC, descrivendo i principali agenti chemioterapici utilizzati, evidenziando il ruolo che svolgono in questo trattamento oncologico. Infine, abbiamo individuato le principali linee di ricerca in questo campo, che sebbene abbiano un ruolo consolidato nelle recenti linee guida, hanno un grande potenziale di sviluppo, con un impatto massimo sulla prognosi dei pazienti con metastasi peritoneali.

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Accession: 066109020

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PMID: 30665226


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