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Progesterone hypersensitivity: Case report with favorable evolution

Progesterone hypersensitivity: Case report with favorable evolution

Experimental and Therapeutic Medicine 17(2): 1125-1127

ISSN/ISBN: 1792-0981

PMID: 30679983

DOI: 10.3892/etm.2018.7055

Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. We report a case of progesterone hypersensitivity in a 27-year old woman with favorable evolution only on topical therapy, the positive clinical outcome being maintained during a subsequent pregnancy and postpartum period.

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Accession: 066121437

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