+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies



Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies



Breast Cancer Research 21(1): 16



Epidemiologic evidence suggests that certain dietary patterns were associated with breast cancer risk, but the results have been inconclusive. We assessed the associations between different dietary patterns and the risk of breast cancer by conducting a meta-analysis of observational studies. Relevant articles were searched in PubMed, Embase, and Cochrane library databases through September 2017. Multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) comparing the highest and lowest categories of Western and prudent dietary patterns were combined by using the random-effects meta-analyses. We identified 32 eligible articles including 14 cohort and 18 case-control studies (34 Western and 35 prudent studies). The pooled analyses found that a Western dietary pattern was associated with a 14% increased risk (RR 1.14, 95% CI 1.02, 1.28), whereas a prudent dietary pattern was associated with an 18% reduced risk of breast cancer (RR 0.82, 95% CI 0.75, 0.89). In addition, sub-group analyses showed that the positive association between a Western dietary pattern and breast cancer risk was significant among postmenopausal (RR 1.20, 95% CI 1.06, 1.35), but not premenopausal women (RR 1.18, 95% CI 0.99, 1.40), and significant for hormone receptor-positive tumors (RR 1.18, 95% CI 1.04, 1.33), but not receptor-negative tumors (RR 0.97, 95% CI 0.83, 1.12). In contrast, the inverse association between a prudent dietary pattern and breast cancer was significant in premenopausal (RR 0.77, 95% CI 0.61, 0.98), but not postmenopausal women (RR 0.88, 95% CI 0.74, 1.03), and significant for both hormone receptor-positive and receptor-negative tumors. The results of the current meta-analysis suggest a possible increased risk of breast cancer associated with a Western dietary pattern and a reduced risk with a prudent dietary pattern. Large-scale cohort studies with a high quality need to be conducted to further confirm the findings of the current meta-analysis. As dietary patterns are modifiable, these findings may provide viable strategies for breast cancer prevention through changes in dietary intake.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066136012

Download citation: RISBibTeXText

PMID: 30696460

DOI: 10.1186/s13058-019-1096-1


Related references

Dietary patterns and risk of colorectal adenoma: a systematic review and meta-analysis of observational studies. Journal of Human Nutrition and Dietetics 29(6): 757-767, 2016

Dietary patterns and breast cancer risk: a systematic review and meta-analysis. American Journal of Clinical Nutrition 91(5): 1294-1302, 2010

Aspirin use and risk of breast cancer: systematic review and meta-analysis of observational studies. Cancer Epidemiology Biomarkers and Prevention 24(11): 1645-1655, 2015

Dietary total antioxidant capacity and risk of cancer: a systematic review and meta-analysis on observational studies. Critical Reviews in Oncology/Hematology 138: 70-86, 2019

Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies. International Journal of Cancer 140(5): 1035-1041, 2017

Dietary Fat Intake and Risk of Ovarian Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies. Nutrition and Cancer 71(6): 939-953, 2019

Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies. Journal of Pharmacy and Pharmaceutical Sciences 19(1): 72-81, 2016

Association between whole grain intake and breast cancer risk: a systematic review and meta-analysis of observational studies. Nutrition Journal 17(1): 87, 2018

Green Tea Consumption and Risk of Breast Cancer and Recurrence-A Systematic Review and Meta-Analysis of Observational Studies. Nutrients 10(12):, 2018

Associations between dietary energy density and obesity: A systematic review and meta-analysis of observational studies. Nutrition 32(10): 1037-1047, 2016

Dietary patterns and CVD: a systematic review and meta-analysis of observational studies. British Journal of Nutrition 114(9): 1341-1359, 2015

Dietary patterns and CVD: a systematic review and meta-analysis of observational studies. British Journal of Nutrition 114(09): 1341-1359, 2015

Ruminant trans-fatty acids and risk of breast cancer: a systematic review and meta-analysis of observational studies. Minerva Endocrinologica 42(4): 385-396, 2017

Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. Annals of Oncology 23(6): 1394-1402, 2012

Dietary patterns and semen quality: a systematic review and meta-analysis of observational studies. Andrology 6(1): 20-28, 2018