+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study

Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study

BMJ Open 9(1): E024689-E024689

Understanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence. In a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland), Helicobacter pylori serum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25-78 years, randomly selected from Israel's population registry in age-sex and population strata. Multivariable logistic regression analyses were performed. Using cut-offs of PGI <30µg/L  or PGI:PGII <3.0, the prevalence of atrophic gastritis was higher among Arab than Jewish participants: 8.8% (95% CIs 7.2% to 10.8%) vs 5.9% (95% CI 4.4% to 7.9%), increasing with age in both groups (p<0.001 for trend). Among Jewish participants, infection with H. pylori CagA phenotype was positively related to atrophic gastritis: adjusted OR (aOR) 2.16 (95% CI 0.94 to 4.97), but not to non-CagA infections aOR 1.17 (95% CI 0.53 to 2.55). The opposite was found among Arabs: aOR 0.09 (95% CI 0.03 to 0.24) for CagA positive and aOR 0.15 (95% CI 0.06 to 0.41) for Cag A negative phenotypes (p<0.001 for interaction). Women had a higher atrophic gastritis prevalence than men. Obesity and smoking were not significantly related to atrophic gastritis; physical activity tended to be inversely associated in Arabs (p=0.08 for interaction). The prevalence of atrophic gastritis was higher among Arabs than Jews and was differently associated with the CagA phenotype.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 066139505

Download citation: RISBibTeXText

PMID: 30700483

DOI: 10.1136/bmjopen-2018-024689

Related references

Coronary heart disease mortality among Arab and Jewish residents of Jerusalem. Lancet 356(9239): 1410-1411, 2000

Prevalence of atrophic gastritis in different populations in Siberia on medical evidence of the serological survey. Klinicheskaia Meditsina 86(7): 35-38, 2008

Prevalence of dental decay in Jewish and Arab schoolchildren in the Jerusalem area. Community Dentistry and Oral Epidemiology 13(2): 97-99, 1985

Inequalities in acute coronary care for acute myocardial infarction between Arab and Jewish residents of Jerusalem Too much or too little?. European Heart Journal 21(Abstract Suppl.): 459, August-September, 2000

Countertransference in cross sectional psychotherapy the example of jewish therapist and arab patient. Psychiatry (New York) 49(1): 69-79, 1986

Role of anti-parietal cell antibody in Helicobacter pylori-associated atrophic gastritis: evaluation in a country of high prevalence of atrophic gastritis. Scandinavian Journal of Gastroenterology 37(3): 287-293, 2002

Role of Anti-Parietal Cell Antibody in Helicobacter pylori -associated Atrophic Gastritis: Evaluation in a Country of High Prevalence of Atrophic Gastritis. Scandinavian Journal of Gastroenterology 37(3): 287-293, 2002

Atrophic gastritis and stomach cancer risk: cross-sectional analyses. Japanese Journal of Cancer Research 83(10): 1041-1046, 1992

Serological evidence of Brucella abortus prevalence in Punjab province, Pakistan--a cross-sectional study. Transboundary and Emerging Diseases 57(6): 443-447, 2010

High prevalence of antibodies to Chlamydia pneumoniae: Determinants of IgG and IgA seropositivity among Jerusalem residents. Epidemiology and Infection 114(3): 465-473, 1995

Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. International Journal of Cancer 35(2): 173-177, 1985

Psychological effects of Helicobacter pylori-associated atrophic gastritis in patients under 50 years: A cross-sectional study. Helicobacter 22(6):, 2017

Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: A cross-sectional study. Cancer Causes and Control 4(4): 307-312, 1993

Helicobacter pylori Infection and Chronic Atrophic Gastritis among Japanese Blood Donors: A Cross-Sectional Study. Cancer Causes & Control 4(4): 307-312, 1993

ABO blood type, Lewis and Secretor genotypes, and chronic atrophic gastritis: a cross-sectional study in Japan. Gastric Cancer 6(1): 8, 2003