Glycated haemoglobin and glycated protein and glucose concentrations in necropsy blood samples

John, W.G.; Scott, K.W.; Hawcroft, D.M.

Journal of Clinical Pathology 41(4): 415-418


ISSN/ISBN: 0021-9746
PMID: 3366927
DOI: 10.1136/jcp.41.4.415
Accession: 066395410

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Glycated haemoglobin and glycated protein (fructosamine) and blood glucose concentrations were measured in blood samples collected from 75 patients at necropsy. Estimation of blood glucose was a poor indicator of glycaemia before death. Measurement of glycated haemoglobin by affinity chromatography distinguished non-diabetic patients from diabetic patients. The distinction was not as clear cut when HbA1 was estimated using electroendosmosis. Seven patients, who at necropsy had no known history of diabetes, had glycated haemoglobin concentrations in the diabetic range. Two of these patients were found to be diabetic, and diabetes had been suspected at some time in another three patients. It is concluded that measurement of glycated haemoglobin or HbA1, in necropsy specimens is a valuable tool for assessing glycaemic control in known diabetic patients, and may be useful in diagnosing previously unsuspected diabetes.