+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes



The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes



Antibiotics 8(1)



The rise in resistance and changes in the spectrum of Candida infections have generated enormous interest in developing new antifungal drugs using natural molecules such as plant essential oils (EOs). Antimicrobial activity against foodborne pathogenic and spoilage microorganisms has been reported for EOs. The goal of this study was to assess the effect of Mentha × piperita essential oil (EO) on C. albicans growth, transition (change from blastospore to hyphae forms), and biofilm formation as well as on the expression of certain virulent genes. We show that whole EO and its vapor attenuated the yeast's growth, compared to that in the control. The effect of the EO was comparable to that of amphotericin-B (AmB). The EO and its vapor significantly decreased the morphological changes of C. albicans, reduced biofilm formation, and disrupted mature C. albicans biofilms. The effect produced by whole EO on biofilm formation/disruption was notably comparable to that observed with AmB. Exposure of C. albicans to EO and its vapor downregulated the expression of various genes, such as secreted aspartyl proteinases (SAP 1, 2, 3, 9, 10) and hyphal wall protein 1 (HWP1). Altogether, these results provide new insight into the efficacy of Mentha × piperita EO against C. albicans and suggest the potential of Mentha × piperita EO for use as an antifungal therapy in multiple applications.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066446149

Download citation: RISBibTeXText

PMID: 30704020

DOI: 10.3390/antibiotics8010010


Related references

The Candida albicans AAA ATPase homologue of Saccharomyces cerevisiae Rix7p (YLL034c) is essential for proper morphology, biofilm formation and activity of secreted aspartyl proteinases. Genetics and Molecular Research 5(4): 664-687, 2006

Inhibitory effects of carvacrol on the expression of secreted aspartyl proteinases 1-3 in fluconazole-resistant Candida albicans isolates. Iranian Journal of Microbiology 8(6): 401-409, 2017

The genes encoding the secreted aspartyl proteinases of Candida albicans constitute a family with at least three members. Infection and Immunity 61(8): 3240-3243, 1993

The expression of Candida albicans secreted aspartyl proteinases during mucosal infections. Mycoses 44(Supplement 1): 53-54, 2001

Expression of Secreted Aspartyl Proteinases in an Experimental Model of Candida albicans-Associated Denture Stomatitis. Journal of Prosthodontics 25(2): 127-134, 2017

Impact of glucose levels on expression of hypha-associated secreted aspartyl proteinases in Candida albicans. Journal of Biomedical Science 21: 22, 2014

The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Molecular Microbiology 28(3): 543-554, 1998

Role of Candida albicans secreted aspartyl protease Sap9 in interkingdom biofilm formation. Pathogens and Disease 74(3), 2016

In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. Journal of Investigative Dermatology 112(3): 383-386, 1999

In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms. Polish Journal of Microbiology 61(4): 247-256, 2013

Candida albicans secreted aspartyl proteinases. Current Topics in Medical Mycology 7(1): 55-69, 1996

Growth, nutrition, and metabolism of Mentha piperita L. IV. Effects of day length and of calcium and potassium on the nitrogenous metabolites of Mentha piperita L. New York Agric Expt Sta Ithaca Mem 379: 68-90, 1962

Growth, nutrition, and metabolism of Mentha piperita L. V. Effects of acute deficiency of specified nutrients on Mentha piperita L. Cornell agric. Exp. Sta. Mem, 379: 91-129, 1962

Three distinct secreted aspartyl proteinases in Candida albicans. Journal of Bacteriology 175(19): 6126-6133, 1993

Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiology and Molecular Biology Reviews 67(3): 400-28, Table of Contents, 2003