+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Real-World Database Examining the Association between Sjögren's Syndrome and Chronic Rhinosinusitis



Real-World Database Examining the Association between Sjögren's Syndrome and Chronic Rhinosinusitis



Journal of Clinical Medicine 8(2)



To investigate the risk of chronic rhinosinusitis (CRS) among patients with Sjögren's syndrome (SS). A total of 18,723 patients diagnosed with SS between 1997 and 2011 were retrospectively analyzed. Moreover, 59,568 patients without SS were matched to patients with SS at a 1:4 ratio on the basis of sex, age, urbanization level, income level, and the comorbidities of rhinitis and nasal sepal deviation. Patients were followed up until death or the end of the study period (31 December, 2013). The primary outcome was the occurrence of CRS. The cumulative incidence of CRS was significantly higher in patients with SS than in those without SS (p < 0.001). The adjusted Cox proportional hazard model showed that patients with SS had a significantly higher incidence of CRS (hazard ratio, 2.51; 95% confidence interval, 2.22⁻2.84; p < 0.001). Sensitivity and subgroup analyses demonstrated SS was an independent risk factor for CRS. The dosage of intranasal corticosteroid spray used was not different between the SS and non-SS groups. Fewer patients with CRS in the SS group underwent sinus surgery (82/407 (20.2%)) than those in the non-SS group (179/667 (26.8%)) and this finding was statistically significant (p = 0.013). The number of operations did not differ significantly between patients with CRS in the SS and non-SS groups. SS is an independent risk factor for CRS. Our study extends the disease spectrum and prompts physicians to be aware of potential CRS occurrence after SS.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066446184

Download citation: RISBibTeXText

PMID: 30704055

DOI: 10.3390/jcm8020155


Related references

Real-world database examining the association between hydroxychloroquine and retinopathy in Taiwan. British Journal of Dermatology 2018, 2018

Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan. Diabetes Care 2018, 2018

The FARSEEING real-world fall repository: a large-scale collaborative database to collect and share sensor signals from real-world falls. European Review of Aging and Physical Activity 13: 8, 2016

Association of CRST syndrome, Gougerot-Sjögren syndrome, thyroid hyperplasia and chronic persistent hepatitis. Schweizerische Rundschau für Medizin Praxis 72(10): 324-328, 1983

Real World Evidence And Costs Of Chronic Heart Failure: Findings From 41,413 Patients Of The Arno Database. Value in Health 18(7): A388, 2015

Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjögren syndrome and non-Sjögren syndrome dry eye patients. Molecular Vision 17: 1397-1404, 2011

Association of Anti-Ro/Sjögren's syndrome type A Antibodies and Complete Atrioventricular Block in an Adult With Sjögren's Syndrome. Archives of Rheumatology 33(2): 225-229, 2018

Sjogren's syndrome no demonstrable association by serology of secondary sjogren's syndrome with cytomegalovirus. Journal of Oral Pathology and Medicine 19(1): 43-44, 1990

A Descriptive analysis of a Real-World Population with Chronic Hepatitis C (CHC) treated with Simeprevir (SMV)- and/or Sofosbuvir (SOF)-based regimens: findings from a us payer database. Value in Health 18(3): A227-A228, 2015

A diagnostic and etiologic studies of Sjögren's syndrome--II. On the relationship between Sjögren's syndrome and chronic thyroiditis. Nihon Jibiinkoka Gakkai Kaiho 92(3): 374-382, 1989

A Real-World Analysis Of Korean Nation-Wide Database: Pattern, Adherence, And Associated Heatlhcare Costs Of Imatinib Among Patients With Chronic Myeloid Leukemia. Value in Health 18(7): A434-A435, 2015

Sjögren's syndrome: managed care data from a large United States population highlight real-world health care burden and lack of treatment options. Clinical and Experimental Rheumatology (): -, 2016

The Chang Gung Research Database-A multi-institutional electronic medical records database for real-world epidemiological studies in Taiwan. Pharmacoepidemiology and Drug Safety 2019, 2019

Increasing Burden of Tyrosine Kinase Inhibitor (TKI) Treatment Failure with Later Lines of Therapy (LOT) in Chronic Myeloid Leukemia (CML): A Real World Retrospective Database Analysis. Value in Health 17(3): A78-A79, 2014

A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study. Rheumatology International 34(2): 191-197, 2014